(HealthDay)—Metformin's role in atherosclerosis may be inhibition of monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation, according to research published online Dec. 31 in Diabetes.
Jan 9, 2015
1
45
Epithelial ovarian cancer is often referred to as a silent killer: Advanced-stage disease has a low survival rate, and in a vast majority of patients, the disease has already spread to other organs at the time of diagnosis ...
Apr 7, 2014
0
0
A Stony Brook University-led international team of infectious disease researchers have discovered how a cellular protein, called STAT3, which is overactive in a majority of human cancers, interferes with an antitumor mechanism ...
Mar 17, 2014
0
0
The increased activation of a key oncogene in head and neck cancers could be the result of mutation and dysfunction of regulatory proteins that are supposed to keep the gene, which has the potential to cause cancer, in check, ...
Jan 6, 2014
0
0
Proper embryonic development depends on a signaling pathway that helps to preserve stem cell "immaturity."
Nov 6, 2013
0
1
(Medical Xpress)—Researchers at Roswell Park Cancer Institute (RPCI) have uncovered a new pathway by which cancer cells, such as in breast cancer, stimulate the expansion of myeloid-derived suppressor cells (MDSCs), a blood ...
Sep 17, 2013
0
0
A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows. The ...
Jun 1, 2013
0
0
After uncovering a mechanism that promotes chronic intestinal inflammation and the development of colorectal cancer, scientists from Virginia Commonwealth University Massey Cancer Center have found that fingolimod, a drug ...
Jan 9, 2013
0
0
Researchers at Moffitt Cancer Center and colleagues have demonstrated that the inhibition of signal transducer and activator of transcription 3 (STAT3) in mouse models of mantle cell lymphoma (MCL), an aggressive and incurable ...
Jul 18, 2012
0
0
Researchers at Boston University School of Medicine (BUSM) have discovered the regulation and functional significance of the acute phase response during a lung infection. The findings, which will be published in the May edition ...
Apr 2, 2012
0
0
