News tagged with statins

Related topics: heart disease · drug · heart attack · cholesterol

AHA: Evolocumab can help substantially reduce LDL

(HealthDay)—Combining statins with the PCSK9 inhibitor evolocumab can help reduce low-density lipoprotein (LDL) cholesterol to previously unseen levels, according to a study published online Nov. 15 in the Journal of the ...

Nov 16, 2016
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Statin

The statins (or HMG-CoA reductase inhibitors) are a class of drugs that lower cholesterol levels in people with or at risk of cardiovascular disease.

They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis. Inhibition of this enzyme in the liver results in decreased cholesterol synthesis as well as increased synthesis of LDL receptors, resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream. The first results can be seen after one week of use and the effect is maximal after four to six weeks.

This text uses material from Wikipedia, licensed under CC BY-SA

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