How genetic therapies transformed the lives of sickle cell patients
Their stories are divided into before and after. First, those long years of pain which flooded every moment—school, relationships, work.
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Their stories are divided into before and after. First, those long years of pain which flooded every moment—school, relationships, work.
23 hours ago
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A team from the University of Ottawa's Faculty of Medicine has completed a new study that reveals the inner workings of gene mutations that result in an ultra-rare syndrome with fewer than 100 reported cases since its first ...
11 hours ago
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Retear and failure to heal are significant post-operative complications in rotator cuff repair surgery despite the use of commercially available rotator cuff repair grafts. Advances in tissue engineering have demonstrated ...
15 hours ago
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Stem cells are cells found in most, if not all, multi-cellular organisms. They are characterized by the ability to renew themselves through mitotic cell division and differentiating into a diverse range of specialized cell types. Research in the stem cell field grew out of findings by Canadian scientists Ernest A. McCulloch and James E. Till in the 1960s. The two broad types of mammalian stem cells are: embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in adult tissues. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialized cells, but also maintain the normal turnover of regenerative organs, such as blood, skin or intestinal tissues.
Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. Highly plastic adult stem cells from a variety of sources, including umbilical cord blood and bone marrow, are routinely used in medical therapies. Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies.
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