News tagged with suppressor genes

A new way to model cancer

Sequencing the genomes of tumor cells has revealed thousands of mutations associated with cancer. One way to discover the role of these mutations is to breed a strain of mice that carry the genetic flaw—but ...

Aug 06, 2014
popularity 5 / 5 (6) | comments 1

30-year puzzle in breast cancer solved

In a new study published today in Cell Reports, scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are ma ...

May 02, 2014
popularity 4.5 / 5 (6) | comments 0

Cancer suppressor gene links metabolism with cellular aging

The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...

Jan 13, 2013
popularity 3.7 / 5 (3) | comments 0 | with audio podcast

Enzyme may be key to cancer progression in many tumors

Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving ...

Nov 26, 2014
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