Medical research

Inflammation accelerates aging of the hematopoietic system

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute ...

Arthritis & Rheumatism

How mitochondrial damage ignites the 'auto-inflammatory fire'

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and ...

Alzheimer's disease & dementia

Studying the link between gum disease and Alzheimer's disease

Fusobacterium nucleatum (F. nucleatum) is a common type of bacteria that proliferates in periodontal disease. It affects the gums and jawbone, and if untreated results in unstable teeth and tooth loss. In recent years, F. ...

Diseases, Conditions, Syndromes

Deconstructing the mechanics of bone marrow disease

Fibrosis is the thickening of various tissues caused by the deposition of fibrillar extracellular matrix (ECM) in tissues and organs as part of the body's wound healing response to various forms of damage. When accompanied ...

Immunology

In colitis patients, skin conditions may originate in the gut

A new study by UC San Francisco researchers reveals how gut inflammation can disrupt not only the digestive system, but also the skin. It's a tale in which the main players are specialized immune cells and the bacterial communities—called ...

Genetics

Researchers ID gene critical to human immune response

Cedars-Sinai investigators have identified a gene that plays an essential role in the innate human immune system. The gene, NLRP11, helps activate the inflammatory response that tells the body's white blood cells to go on ...

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