News tagged with tamoxifen
Scientists find new drug target in breast cancer
Researchers have identified a new protein involved in the development of drug resistance in breast cancer which could be a target for new treatments, they report today in the journal Nature Medicine.
Cancer
May 22, 2011 |
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Tamoxifen ameliorates symptoms of Duchenne muscular dystrophy
A new study has found that tamoxifen, a well-known breast cancer drug, can counteract some pathologic features in a mouse model of Duchenne muscular dystrophy (DMD). At present, no treatment is known to produce ...
Diseases, Conditions, Syndromes
Jan 15, 2013 |
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Ability to metabolize tamoxifen affects breast cancer outcomes, study confirms
For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer ...
Cancer
Dec 27, 2012 |
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Scientists unravel resistance to breast cancer treatment
Scientists have identified a molecular 'flag' in women with breast cancer who do not respond or have become resistant to the hormone drug tamoxifen.
Cancer
Oct 31, 2012 |
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Breast cancer recurrence defined by hormone receptor status
Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research shows ...
Cancer
Oct 01, 2012 |
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New hope for thousands of women with most aggressive breast cancer
(Medical Xpress)—Scientists at The University of Nottingham have identified a protein which could help predict survival outcomes for women with the most aggressive forms of breast cancer.
Cancer
Sep 07, 2012 |
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Possible therapy for tamoxifen resistant breast cancer identified
(Medical Xpress)—A study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has discovered how tamoxifen-resistant ...
Cancer
Aug 30, 2012 |
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MicroRNA controls malignancy and resistance of breast cancer cells
Many breast cancer patients are treated with a drug called tamoxifen. The substance blocks the effect of estrogen and thus suppresses the growth signals of this hormone in cancer cells. When resistance to the drug develops, ...
Cancer
May 04, 2012 |
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Decision guide reduced uncertainty over breast cancer prevention, study finds
When women at high risk of breast cancer viewed a customized web-based decision guide about prevention options, they were more likely to make a choice about prevention and to feel comfortable with their choice, a new study ...
Cancer
Apr 15, 2012 |
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Study links breast cancer resistance with timing of soy consumption
Studies exploring the relationship between soy consumption and breast cancer have been mixed, but new research introduces a new thought: Could women with breast cancer who began eating soy as an adult develop a tumor more ...
Cancer
Apr 02, 2012 |
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Researchers identify possible receptor for key breast cancer regulator
A key protein potentially involved in regulating breast cancer progression has been identified by researchers at Clarkson University in Potsdam, N.Y. Led by professor Costel Darie, the team worked to identify the binding ...
Cancer
Jan 13, 2012 |
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Tamoxifen resistance -- and how to defeat it
In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the treatment at all, or because ...
Cancer
Nov 13, 2011 |
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Small molecules can starve cancer cells
All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased ...
Cancer
Oct 09, 2011 |
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Leukemia drug reverses tamoxifen-resistance in breast cancer cells
Taking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. ...
Cancer
Aug 01, 2011 |
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Drug's lasting benefits sees breast cancer deaths down by third
The benefits of using tamoxifen to prevent recurrence of breast cancer after surgery continue to accrue long after women stop taking the drug, a study led by Oxford University has found.
Cancer
Jul 29, 2011 |
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Tamoxifen
Tamoxifen is an antagonist of the estrogen receptor in breast tissue and is therefore used in the treatment of breast cancer. As of 2004, it was the world's largest selling drug for that purpose.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."
For more information about Tamoxifen, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
