News tagged with tangles
Genetic markers ID second Alzheimer's pathway
Researchers at Washington University School of Medicine in St. Louis have identified a new set of genetic markers for Alzheimer's that point to a second pathway through which the disease develops.
Alzheimer's disease & dementia
Apr 04, 2013 |
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Untangling the mysteries of Alzheimer's
One of the most distinctive signs of the development of Alzheimer's disease is a change in the behavior of a protein that neuroscientists call tau. In normal brains, tau is present in individual units essential to neuron ...
Neuroscience
Feb 02, 2012 |
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Transmission of tangles in Alzheimer's mice provides more authentic model of tau pathology
Brain diseases associated with the misformed protein tau, including Alzheimer's disease and frontotemporal lobar degeneration with tau pathologies, are characterized by neurofibrillary tangles (NFTs) comprised ...
Neuroscience
Jan 15, 2013 |
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Overlooked peptide reveals clues to causes of Alzheimer's disease
Researchers at the RIKEN Brain Science Institute (BSI) and their collaborators have shed light on the function of a little-studied amyloid peptide in promoting Alzheimer's disease (AD). Their surprising findings reveal that ...
Neuroscience
Jul 03, 2011 |
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Discovery of molecular pathway of Alzheimer's disease reveals new drug targets
The discovery of the molecular pathway that drives the changes seen in the brains of Alzheimer's patients is reported today, revealing new targets for drug discovery that could be exploited to combat the disease. The study ...
Alzheimer's disease & dementia
Nov 20, 2012 |
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Imaging technique IDs plaques, tangles in brains of severely depressed older adults
Depression is one of the most common mental disorders in the elderly, but little is known about the underlying biology of its development in older adults.
Psychology & Psychiatry
Nov 08, 2011 |
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Protecting your brain: 'Use it or lose it'
The findings of a new study suggest that the protective effects of an active cognitive lifestyle arise through multiple biological pathways.
Psychology & Psychiatry
Apr 25, 2012 |
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Brain-imaging tool and stroke risk test help identify cognitive decline early
UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia.
Neuroscience
Apr 03, 2013 |
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Alzheimer's: French scientists focus on key target
French scientists said on Tuesday that lack of a key brain protein was linked to Alzheimer's, a finding that threw up a tempting target for drugs to fight the disease.
Neuroscience
Jan 24, 2012 |
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Cancer drug improves memory in mouse model of Alzheimer's disease
A compound that previously progressed to Phase II clinical trials for cancer treatment slows neurological damage and improves brain function in an animal model of Alzheimer's disease, according to a study ...
Alzheimer's disease & dementia
Mar 13, 2012 |
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Tau transmission model opens doors for new Alzheimer's, Parkinson's therapies
Injecting synthetic tau fibrils into animal models induces Alzheimer's-like tau tangles and imitates the spread of tau pathology, according to research from the Perelman School of Medicine at the University of Pennsylvania ...
Neuroscience
Mar 15, 2013 |
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New hope for treating Alzheimer's Disease: A role for the FKBP52 protein
New research in humans published today reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer's drugs and for detecting ...
Alzheimer's disease & dementia
Mar 20, 2012 |
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The tangled web in Alzheimer's protein deposits is more complex than once thought
Scientists from the National Institutes of Health in the United States have made an important discovery that should forever change the scope and direction of Alzheimer's research. Specifically, they have discovered that the ...
Neuroscience
Nov 01, 2011 |
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Chemical engineers help decipher mystery of neurofibrillary tangle formation in Alzheimer's brains
Neurofibrillary tangles – odd, twisted clumps of protein found within nerve cells – are a pathological hallmark of Alzheimer's disease. The tangles, which were first identified in the early 1900s by German psychiatrist ...
Medical research
Nov 02, 2011 |
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Researchers find new target for Alzheimer's drug development
Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.
Alzheimer's disease & dementia
Dec 03, 2012 |
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