Inhibition of PBEF is a possible therapeutic target for pulmonary hypertension
Inhibition of pre-B Cell Colony-Enhancing Factor (PBEF) could be a potential therapeutic target for pulmonary hypertension (PH), according to a preclinical study in an animal model of PH.
Diseases, Conditions, Syndromes
May 22, 2012 |
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Scientists identify protein that stimulates brown fat to burn calories
Scientists have identified a protein which regulates the activation of brown fat in both the brain and the body's tissues. Their research, which was conducted in mice, was published today, Friday 11 May, in the journal Cell.
Medical research
May 10, 2012 |
4.6 / 5 (5) |
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Scientists discover new inflammatory target
(Medical Xpress) -- Scientists from Queen Mary, University of London have found a new therapeutic target to combat inflammation.
Inflammatory disorders
May 09, 2012 |
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How does the immune system fight off threats to the brain?
Like a police officer calling for backup while also keeping a strong hold on a suspected criminal, immune cells in the brain take a two-tier approach to fighting off a threat, new research from the University ...
Medical research
Apr 30, 2012 |
5 / 5 (3) |
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Advanced pancreatic tumors depend on continued oncogene activity
Researchers at Dana-Farber Cancer Institute have shown that advanced pancreatic cancers in mice can't survive without continued expression of a mutant oncogene that "rewires" key metabolic pathways to fuel the cancer cells.
Cancer
Apr 26, 2012 |
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New biomarker may predict prognosis for patients with chronic lymphocytic leukemia
Researchers at the University of California-San Diego School of Medicine have shown that G protein-coupled receptor expression may predict the prognosis of patients with chronic lymphocytic leukemia. Their findings may identify ...
Cancer
Apr 24, 2012 |
5 / 5 (1) |
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New stem cell found in the brain
Researchers at Lund University in Sweden have discovered a new stem cell in the adult brain. These cells can proliferate and form several different cell types - most importantly, they can form new brain cells. Scientists ...
Medical research
Apr 20, 2012 |
5 / 5 (2) |
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Cellular pathway linked to diabetes, heart disease
Cardiac researchers at the University of Cincinnati (UC) have found that a certain cellular pathway is linked to obesity-related disorders, like diabetes, heart disease and fatty liver disease.
Medical research
Apr 19, 2012 |
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Scientists find new breast cancer genes, rewrite rulebook
Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next-generation treatments.
Cancer
Apr 18, 2012 |
4.5 / 5 (2) |
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Scientists tailor cell surface targeting system to hit organelle ZIP codes
Scientists who developed a technology for identifying and targeting unique protein receptor ZIP Codes on the cellular surface have found a way to penetrate the outer membrane and deliver engineered particles - called iPhage ...
Medical research
Apr 17, 2012 |
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Target set on cancer gene MCL1
A research team pursuing one of the most commonly altered genes in cancer has laid a critical foundation for understanding this gene that could point the way toward developing drugs against it. A recent study of cancer genetics ...
Cancer
Apr 16, 2012 |
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KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
Testing patients with non-small cell lung cancer for both mutations and amplifications of the KRAS gene prior to therapy may help to predict response to treatment with antifolates, according to the updated results of a preclinical ...
Cancer
Apr 04, 2012 |
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Study: Epstein Barr virus protects against autoimmune disease
To the surprise of investigating researchers, an animal model of Epstein Barr virus protected lupus-prone mice against development of the autoimmune disease. Earlier work had suggested that EBV might promote the development ...
Immunology
Apr 02, 2012 |
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Rare immune cells could hold key to treating immune disorders
The characterisation of a rare immune cell's involvement in antibody production and ability to 'remember' infectious agents could help to improve vaccination and lead to new treatments for immune disorders, say researchers ...
Immunology
Apr 02, 2012 |
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'Druggable' protein complex identified as a therapeutic target in acute myeloid leukemia
Scientists at Cold Spring Harbor Laboratory have identified a candidate drug target for treating acute myeloid leukemia (AML), a white blood cell cancer that proliferates out of control in the bone marrow. The team, led by ...
Cancer
Apr 02, 2012 |
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