News tagged with target proteins
Compound stimulates tumor-fighting protein in cancer therapy
A compound that stimulates the production of a tumor-fighting protein may improve the usefulness of the protein in cancer therapy, according to a team of researchers.
Cancer
Feb 06, 2013 |
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A scanner for hereditary defects
Our genetic material is constantly exposed to damage, which the body's own proteins normally repair. One of these proteins works like a scanner, continually scouring the genetic material for signs of damage. ...
Genetics
Jan 24, 2013 |
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First special edition updating progress on efforts to map human proteins
Almost 10 years after completion of the Human Genome Project in 2003, scientists are making progress toward the next major goal in applying the genetic information in that "Book of Life" in medicine, leaders of an international ...
Genetics
Jan 23, 2013 |
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Hepatitis B virus promotes oncogenesis through microRNA modulation
Viruses prompt oncogenic transformation by genetically altering infected cells. Several recent studies have demonstrated that viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression ...
Diseases, Conditions, Syndromes
Jan 16, 2013 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Discovery promises to improve drugs used to fight cancer, other diseases
(Medical Xpress)—Even when at rest, the human body is a flurry of activity. Like a microscopic metropolis locked in a state of perpetual rush hour traffic, the trillions of cells that make us who we are work feverishly ...
Medical research
Jan 11, 2013 |
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Fusion gene contributes to glioblastoma progression
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.
Cancer
Jan 09, 2013 |
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Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Immunology
Jan 09, 2013 |
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Scientists use 'virtual experiments' to uncover missing cancer targets
(Medical Xpress)—Scientists have identified 46 previously overlooked but potentially 'druggable' cancer targets, using a powerful new online approach that allows researchers to carry out 'virtual experiments' to quickly ...
Cancer
Jan 02, 2013 |
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The factor that could influence future breast cancer treatment
Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. ...
Cancer
Dec 27, 2012 |
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Protein kinase Akt identified as arbiter of cancer stem cell fate, paper reports
(Medical Xpress)—The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author ...
Cancer
Dec 20, 2012 |
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Removing protein 'garbage' in nerve cells may help control two neurodegenerative diseases
Neuroscientists at Georgetown University Medical Center say they have new evidence that challenges scientific dogma involving two fatal neurodegenerative diseases—amyotrophic lateral sclerosis (ALS), and frontotemporal ...
Medical research
Dec 20, 2012 |
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New research discovery provides therapeutic target for ALS
Research led by Dr. Udai Pandey, Assistant Professor of Genetics at LSU Health Sciences Center New Orleans, has found that the ability of a protein made by a gene called FUS to bind to RNA is essential to the development ...
Genetics
Dec 19, 2012 |
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Harnessing the ID in glioma
Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural ...
Cancer
Dec 17, 2012 |
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Novel antibodies for combating Alzheimer's and Parkinson's disease
Antibodies developed by researchers at Rensselaer Polytechnic Institute are unusually effective at preventing the formation of toxic protein particles linked to Alzheimer's disease and Parkinson's disease, ...
Neuroscience
Dec 03, 2012 |
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