Medicinal toothbrush tree yields antibiotic to treat TB in new way
A compound from the South African toothbrush tree inactivates a drug target for tuberculosis in a previously unseen way.
Diseases, Conditions, Syndromes
Jan 14, 2013 |
5 / 5 (1) |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
3.7 / 5 (3) |
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Discovery promises to improve drugs used to fight cancer, other diseases
(Medical Xpress)—Even when at rest, the human body is a flurry of activity. Like a microscopic metropolis locked in a state of perpetual rush hour traffic, the trillions of cells that make us who we are work feverishly ...
Medical research
Jan 11, 2013 |
4.3 / 5 (3) |
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Researchers foresee new therapies and diagnostics for deadly fibrotic diseases
A team of scientists has developed a playbook for ending the devastating impact of fibrotic diseases of the liver, lung, kidney, and other organs, which are responsible for as many as 45 percent of all deaths in the industrialized ...
Medical research
Jan 09, 2013 |
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Fusion gene contributes to glioblastoma progression
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.
Cancer
Jan 09, 2013 |
5 / 5 (1) |
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Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Immunology
Jan 09, 2013 |
5 / 5 (1) |
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From protein signaling to cancer drug development
(Medical Xpress)—Living organisms depend on proteins for their survival. These large, complex molecules mediate nearly every life function, but when the genes that code for them start to mutate, ...
Cancer
Jan 08, 2013 |
5 / 5 (1) |
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Study: Most-used diabetes drug works in different way than previously thought
A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University ...
Diabetes
Jan 06, 2013 |
5 / 5 (3) |
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Telmisartan reverses insulin resistance in mice
(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, ...
Diabetes
Jan 03, 2013 |
5 / 5 (1) |
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Scientists use 'virtual experiments' to uncover missing cancer targets
(Medical Xpress)—Scientists have identified 46 previously overlooked but potentially 'druggable' cancer targets, using a powerful new online approach that allows researchers to carry out 'virtual experiments' to quickly ...
Cancer
Jan 02, 2013 |
5 / 5 (2) |
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The factor that could influence future breast cancer treatment
Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. ...
Cancer
Dec 27, 2012 |
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Cellular metabolism arms T cells to battle viruses and tumours
(Medical Xpress)—New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the development of tumours.
Medical research
Dec 24, 2012 |
5 / 5 (4) |
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Three new genetic links to colorectal cancer
Vanderbilt-Ingram Cancer Center investigators have identified three new genetic "hotspots" linked to colorectal cancer. These variants, reported Dec. 23 in an Advanced Online Publication in Nature Genetics, provide new in ...
Cancer
Dec 23, 2012 |
5 / 5 (1) |
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Targeted gene silencing drugs are more than 500 times more effective with new delivery method
Small interfering RNAs (siRNAs) are a potent new drug class that can silence a disease-causing gene, but delivering them to a target cell can be challenging. An innovative delivery approach that dramatically ...
Medical research
Dec 21, 2012 |
5 / 5 (2) |
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World-first tissue study could re-shape future of advanced prostate cancer treatment
The first-ever comprehensive study of prostate cancer tissue has revealed a completely new gene network driving the disease in patients who have stopped responding to standard hormone treatment, according ...
Cancer
Dec 21, 2012 |
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