The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) plays an important and previously unknown role in blocking a form of cell death called ferroptosis, according to a new study published today in Nature by researchers ...
May 12, 2021
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91
Parkinson's disease (PD) is well known as a debilitating disease that gradually worsens over time. Although the disease's progression has been largely tied to the loss of motor functions, non-motor symptoms, including the ...
Apr 5, 2021
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108
Tapping into an ancient evolutionary survival mechanism, cancer cells enter into a sluggish, slow-dividing state to survive the harsh environment created by chemotherapy or other targeted agents.
Jan 7, 2021
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484
Being traumatized can cause what are known as dissociative symptoms—such as experiencing amnesia, an out-of-body experience, feeling emotionally numb—which may help people cope. Experiencing these symptoms intensely or ...
Sep 25, 2020
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240
Targeting overactive immune cells and dampening their chronic neurotoxic effects may offer new therapeutic strategies for traumatic brain injury (TBI), according to new preclinical research in mice, which has been published ...
Feb 24, 2020
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303
Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer cells use the host's own immune system to grow and spread, ultimately becoming deadly. Immune cells like macrophages, ...
Jan 30, 2020
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In patients with Alzheimer's disease, amyloid-beta protein fragments accumulate in the tissue and blood vessels of the brain, likely due to a faulty clearance mechanism. In experiments conducted in mice, investigators at ...
Dec 3, 2019
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816
Lung cancer cells use antioxidants, endogenous or dietary, to spread in the body by activating a protein called BACH1 and increasing the uptake and use of sugar, Swedish and American researchers report in two independent ...
Jun 27, 2019
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Researchers from the Institute of Neuroscience and their collaborators have revealed a new cellular mechanism for amyotrophic lateral sclerosis (ALS), suggesting a novel therapeutic strategy targeting the RNA degradation ...
Apr 9, 2019
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2
New findings by researchers at Cardiff University suggest that intensive therapy during the early stages of multiple sclerosis (MS) leads to better long-term outcomes for patients, despite it often being viewed as a riskier ...
Feb 20, 2019
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