News tagged with transcription factors
Related topics: genes , cells , gene expression , stem cells , dna sequences
Protein central to cancer stem cell formation provides new potential target
Researchers have identified a pivotal protein in a cellular transformation that makes a cancer cell more resistant to treatment and more capable of growing and spreading, making it an inviting new target for drug development.
Cancer
Feb 13, 2013 |
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Regulating single protein prompts fibroblasts to become neurons
Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells – abundantly found in connective tissues – into functional neurons. The findings, which could have far-reaching ...
Medical research
Jan 10, 2013 |
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Multiple sclerosis drug may one day treat colorectal cancer
After uncovering a mechanism that promotes chronic intestinal inflammation and the development of colorectal cancer, scientists from Virginia Commonwealth University Massey Cancer Center have found that fingolimod, ...
Cancer
Jan 09, 2013 |
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Gene therapy reprograms scar tissue in damaged hearts into healthy heart muscle
A cocktail of three specific genes can reprogram cells in the scars caused by heart attacks into functioning muscle cells, and the addition of a gene that stimulates the growth of blood vessels enhances that effect, said ...
Cardiology
Jan 04, 2013 |
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The factor that could influence future breast cancer treatment
Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. ...
Cancer
Dec 27, 2012 |
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Protein kinase Akt identified as arbiter of cancer stem cell fate, paper reports
(Medical Xpress)—The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author ...
Cancer
Dec 20, 2012 |
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Study reveals alternative pathway through which beta-catenin drives colon cancer
Colon cancer is one of the leading causes of cancer-related death in the United States. Risk factors for the disease are varied and include factors such as advanced age and diet, but most cases share something ...
Cancer
Dec 14, 2012 |
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Researches discovered genes that predict whether trastuzumab will work for breast cancer patients
Adding the drug trastuzumab to chemotherapy prevents cancer recurrence and improves survival in a large number of women with early stage HER2-positive breast cancer. But trastuzumab does not stop tumors from returning in ...
Cancer
Dec 08, 2012 |
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Novel studies of gene regulation in brain development may mean new treatment of mental disorders
(Phys.org)—A team of researchers at the University of California, San Diego and the Institut Pasteur, Paris has come up with a novel way to describe a time-dependent brain development based on coherent–gene-groups (CGGs) ...
Genetics
Dec 02, 2012 |
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X-ray analysis deciphers master regulator important for skin cancer
With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, ...
Cancer
Dec 01, 2012 |
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Traffic cops of the immune system: Molecule called IKBNS in charge of regulatory immune cell maturation
A certain type of immune cell—the regulatory T cell, or Treg for short—is in charge of putting on the brakes on the immune response. In a way, this cell type might be considered the immune system's traffic cops.
Immunology
Nov 29, 2012 |
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Genome packaging: Key to breast cancer development
Cancer is a complex disease and only thanks to advances in genomic techniques have researchers begun to understand, at a cellular and molecular level, the mechanisms which are disrupted in cancer cells. This ...
Cancer
Nov 22, 2012 |
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A more complicated network than generally accepted may control maturation of B cells in the immune system
The process of blood cell development, known as hematopoiesis, gives rise to numerous different immune cell subtypes. Each of these in turn matures through a stepwise process governed by the action of transcription ...
Medical research
Nov 22, 2012 |
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Two heads are better than one: Gene expression reveals molecular mechanisms underlying evolution of cerebral cortex
Dramatic expansion of the human cerebral cortex, over the course of evolution, accommodated new areas for specialized cognitive function, including language. Understanding the genetic mechanisms underlying ...
Neuroscience
Nov 09, 2012 |
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A protein's role in helping cells repair DNA damage
(Medical Xpress)—In a new study, University at Buffalo scientists describe the role that a protein called TFIIB plays in helping cells repair DNA damage, a critical function for preventing the growth of tumors.
Medical research
Nov 01, 2012 |
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