News tagged with transcription factors

Related topics: genes , cells , gene expression , stem cells , dna sequences

Why the immune system fails to kill HIV

Our immune system contains CD8+ T cells which protect us from various diseases such as cancer and viruses. Some of them are specifically tasked with killing cells infected with the HIV virus – and researchers ...

Jul 18, 2014
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Researchers uncover genetic cause of childhood leukemia

For the first time, a genetic link specific to risk of childhood leukemia has been identified, according to a team of researchers from Memorial Sloan-Kettering Cancer Center, St. Jude Children's Research Hospital, University ...

Sep 08, 2013
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New compound discovered that rapidly kills liver cancer

Scientists have identified a new compound that rapidly kills hepatocellular carcinoma (HCC) cells, the most common form of liver cancer and fifth most common cancer worldwide, while sparing healthy tissue. The compound, Factor ...

Mar 14, 2012
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How mom's immune system is linked to autism risk

(Medical Xpress)—Activating a mother's immune system during her pregnancy disrupts the development of neural cells in the brain of her offspring and damages the cells' ability to transmit signals and communicate with one ...

Sep 23, 2013
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Between B cells and T cells

Mature cells develop through a number of immature stages. During this process, they must remember the specialization they are committed to. For immune system B cells, Rudolf Grosschedl of the Max Planck Institute of Immunobiology ...

Jul 23, 2013
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Key protein accelerates diabetes in two ways

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham (UAB) study published online today ...

Aug 26, 2013
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Transcription factor

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.

A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.

This text uses material from Wikipedia licensed under CC BY-SA