News tagged with transcription factors
Research finds key molecules involved in forming long-term memories
How does one's experience of an event get translated into a memory that can be accessed months, even years later? A team led by University of Pennsylvania scientists has come closer to answering that question, identifying ...
Medical research
Sep 10, 2012 |
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Study uncovers molecular role of gene linked to blood vessel formation
University of North Carolina researchers have discovered that disrupting a gene that acts as a regulatory switch to turn on other genes can keep blood vessels from forming and developing properly.
Medical research
Apr 29, 2013 |
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Neurons derived from cord blood cells may represent new therapeutic option
For more than 20 years, doctors have been using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses, from cancer and immune disorders to blood ...
Medical research
Jul 16, 2012 |
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New compound discovered that rapidly kills liver cancer
Scientists have identified a new compound that rapidly kills hepatocellular carcinoma (HCC) cells, the most common form of liver cancer and fifth most common cancer worldwide, while sparing healthy tissue. The compound, Factor ...
Cancer
Mar 14, 2012 |
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Gene regenerates heart tissue, critical finding for heart failure prevention
Researchers at UT Southwestern Medical Center have identified a specific gene that regulates the heart's ability to regenerate after injuries.
Genetics
Apr 17, 2013 |
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Study finds how to shutdown cancer's powerful master protein
The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex ...
Immunology
Mar 03, 2013 |
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Team finds markers related to ovarian cancer survival and recurrence
(Medical Xpress)—Researchers at the University of Illinois have identified biomarkers that can be used to determine ovarian cancer survival and recurrence, and have shown how these biomarkers interact with ...
Cancer
Apr 30, 2013 |
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Study finds how stress, depression can shrink the brain
Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered ...
Psychology & Psychiatry
Aug 12, 2012 |
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ENCODE project: Yale team finds order amidst the chaos within the human genome
The massive Encyclopedia of DNA Elements (ENCODE) unveiled Sept. 5 reveals a human genome vastly more rich and complex than envisioned even a decade ago. In a key supporting paper published in the journal Nature, the lab of ...
Genetics
Sep 05, 2012 |
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Regulating single protein prompts fibroblasts to become neurons
Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells – abundantly found in connective tissues – into functional neurons. The findings, which could have far-reaching ...
Medical research
Jan 10, 2013 |
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Researchers and colleagues identify PHF20, a regulator of gene P53
Researchers at Moffitt Cancer Center and colleagues have identified PHF20, a novel transcriptional factor, and clarified its role in maintaining the stability and transcription of p53, a gene that allows for both normal cell ...
Cancer
Aug 24, 2012 |
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Scientists show how fatty diets cause diabetes
Newly diagnosed type 2 diabetics tend to have one thing in common: obesity. Exactly how diet and obesity trigger diabetes has long been the subject of intense scientific research. A new study led by Jamey ...
Medical research
Aug 14, 2011 |
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Research team discovers genes and disease mechanisms behind a common form of muscular dystrophy
Continuing a series of groundbreaking discoveries begun in 2010 about the genetic causes of the third most common form of inherited muscular dystrophy, an international team of researchers led by a scientist at Fred Hutchinson ...
Cancer
Jan 12, 2012 |
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SUMO-snipping protein plays crucial role in T and B cell development
When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at The University of Texas ...
Genetics
Jan 27, 2012 |
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Smokers could be more prone to schizophrenia, study finds
Smoking alters the impact of a schizophrenia risk gene. Scientists from the universities of Zurich and Cologne demonstrate that healthy people who carry this risk gene and smoke process acoustic stimuli in a similarly deficient ...
Diseases, Conditions, Syndromes
Mar 26, 2012 |
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Transcription factor
In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.
A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.
For more information about Transcription factor, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
