Oncology & Cancer

Searching for the 'signature' causes of BRCAness in breast cancer

Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature (a pattern of base swaps—e.g., Ts for Gs, Cs for As—throughout a genome) known in cancer genomics as "Signature ...

Neuroscience

Researchers define two categories of multiple sclerosis patients

There are approximately 400,000 people in the United States with multiple sclerosis. Worldwide, the number jumps to more than 2.1 million people. Rather than a one-size-fits-all approach to treating the millions with multiple ...

Oncology & Cancer

Future prostate cancer treatments might be guided by math

Scientists have designed a first draft of a mathematical model that someday could guide treatment decisions for advanced prostate cancer, in part by helping doctors predict how individual patients will respond to therapy ...

Medical research

Cancer stem cells made, not born

In cancer, tumors aren't uniform: they are more like complex societies, each with a unique balance of cancer cell types playing different roles. Understanding this "social structure" of tumors is critical for treatment decisions ...

Psychology & Psychiatry

After cardiac arrest, family members need support, too

Family members or loved ones who must make treatment decisions for people who have survived cardiac arrest benefited greatly from resources and interventions to help guide their decisions and provide support for them throughout ...

Medical research

Nonsurgical treatment shows advantages in Peyronie's disease

For men with Peyronie's disease (PD), nonsurgical treatment including injections of collagenase clostridium histolyticum (CCH) produces high satisfaction with sexual outcomes—with fewer adverse events compared to surgery. ...

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