News tagged with tumor biology
Common genetic alteration found in head and neck cancers may not be key to effective treatment
Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that d ...
Cancer
Jan 29, 2013 |
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Preclinical study identifies 'master' proto-oncogene that regulates ovarian cancer metastasis
Scientists at The University of Texas MD Anderson Cancer Center have discovered the signaling pathway whereby a master regulator of cancer cell proteins – known as Src – leads to ovarian cancer progression when exposed ...
Cancer
Jan 29, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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Genes behind aggressive endometrial cancer found
In a major breakthrough for uterine serous carcinoma (USC)—a chemo-resistant, aggressive form of endometrial cancer, Yale researchers have defined the genetic landscape of USC tumors, findings that point to new treatment ...
Cancer
Jan 28, 2013 |
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DNA-repairing protein may be key to preventing recurrence of some cancers
Just as the body can become resistant to antibiotics, certain methods of killing cancer tumors can end up creating resistant tumor cells. But a University of Central Florida professor has found a protein ...
Cancer
Jan 28, 2013 |
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Researchers identify possible drug target in breast cancer metastasis
The spread of breast cancer to distant organs within the body, an event that often leads to death, appears in many cases to involve the loss of a key protein, according to UC San Francisco researchers, whose new discoveries ...
Cancer
Jan 27, 2013 |
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Gene sequencing project mines data once considered 'junk' for clues about cancer
Genome sequencing data once regarded as junk is now being used to gain important clues to help understand disease. The latest example comes from the St. Jude Children's Research Hospital – Washington University Pediatric ...
Cancer
Jan 24, 2013 |
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Cancer biology: Keeping bad company
The p53 tumor suppressor protein manages DNA repair mechanisms in response to genetic damage and kills off precancerous cells before they multiply. The loss of p53 due to mutation greatly increases risk of ...
Cancer
Jan 16, 2013 |
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Scientists reveal aggressive breast cancer's metastatic path
Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away from a primary tumor ...
Cancer
Jan 14, 2013 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Study unmasks regulator of healthy life span
A new series of studies in mouse models by Mayo Clinic researchers uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and ...
Medical research
Dec 17, 2012 |
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Improving the development of new cancer models using an advanced biomedical imaging method
Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging (MRI) method can non-invasively evaluate the cellular ...
Cancer
Dec 17, 2012 |
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MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
Between the blueprint of the genome and the products of its expression lie microRNAs, which can boost or lower the rate at which genes become stuff. In fact, many cancers use microRNA to magnify the expression of faulty genes ...
Cancer
Dec 13, 2012 |
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Research identifies targeted molecular therapy for untreatable NF1 tumors
Researchers conducting a preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors that develop in people with the genetic disorder Neurofibromatosis 1 (NF1).
Cancer
Dec 10, 2012 |
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To fight incurable metastatic breast cancer, resistance must be broken
One of the most frustrating truths about cancer is that even when a treatment works, it often doesn't work for long because cancer cells find ways to resist. However, researchers reporting studies done in mice in the December ...
Cancer
Dec 10, 2012 |
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