News tagged with tumor metabolism
Limits to growth: Scientists identify key metastasis-enabling enzyme
(Medical Xpress) -- On the complex road to eradicating cancer, controlling or preventing metastatic growth initiated by primary tumors is high on the to-do list. A key area of such research is the development ...
Medical research
May 22, 2012 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Breast cancer risk linked to early-life diet and metabolic syndrome
Striking new evidence suggesting that diet and related factors early in life can boost the risk for breast cancer—totally independent of the body's production of the hormone estrogen—has been uncovered by a team of researchers ...
Cancer
Sep 17, 2012 |
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Cancer cell metabolism kills
Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply ...
Cancer
Apr 15, 2013 |
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Mitochondrial metabolic regulator SIRT4 guards against DNA damage
(Medical Xpress)—Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.
Cancer
Apr 05, 2013 |
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The metabolic weathervane of cancer
Highly expressed in various cancers and known for its cytoprotective properties, TRAP1 protein has been identified as a potential target for antitumor treatments. As a result of the research conducted by Len Neckers, from ...
Cancer
Apr 01, 2013 |
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Scientists find potential loophole in pancreatic cancer defenses
Dana-Farber Cancer Institute scientists and colleagues have discovered that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control ...
Cancer
Mar 27, 2013 |
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BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, ...
Cancer
Mar 08, 2013 |
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Study shows key enzyme missing from aggressive form of breast cancer
A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain—providing insight ...
Cancer
Feb 28, 2013 |
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Scientists identify molecular link between metabolism and breast cancer
(Medical Xpress)—A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers ...
Cancer
Feb 06, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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Protein controlling glucose metabolism also a tumor suppressor
A protein known to regulate how cells process glucose also appears to be a tumor suppressor, adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. In their report in the Dec. ...
Cancer
Dec 06, 2012 |
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Metabolic protein launches sugar feast that nurtures brain tumors
Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which ...
Cancer
Nov 26, 2012 |
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Researchers identify novel metabolic programs driving aggressive brain tumors
Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain.
Cancer
Nov 09, 2012 |
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A novel oncogenic network specific to liver cancer initiation
Researchers headed by Erwin Wagner, the Director of the BBVA Foundation-CNIO Cancer Cell Biology Programme at the Spanish National Cancer Research Centre (CNIO), have deciphered how a stress-inducible gene regulator, AP-1, ...
Cancer
Oct 07, 2012 |
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