There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer - drugs that turn them off ...
Oct 10, 2017
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An international team of researchers at University of California San Diego School of Medicine and Moores Cancer Center, with colleagues at Sun Yet-sun University Cancer Center and other collaborating institutions, have developed ...
Oct 9, 2017
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Cancers driven by mutations in the KRAS gene are among the most deadly. For decades, researchers have tried unsuccessfully to directly target mutant KRAS proteins as a means to treat tumors. Instead of targeting mutant KRAS ...
Sep 27, 2017
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Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called "epigenetic" changes in the cells ...
Sep 11, 2017
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UCLA researchers have discovered that timing is everything when it comes to preventing a specific gene mutation in mice from developing rare and fast-growing cancerous tumors, which also affects young children. This mutation ...
Aug 22, 2017
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The TET2 tumor suppressor gene helps guard against blood cancers and perhaps protects against heart disease. Mutations in the gene affect about 1% of people over the age of 65, making them more susceptible to those diseases. ...
Aug 16, 2017
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A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.
Jul 24, 2017
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Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of cancer. As opposed ...
Jun 12, 2017
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Scientists have gotten a better look at the effects of a gene known as the "guardian of the genome" in causing premature births and miscarriages.
May 25, 2017
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The loss of the tumor suppressor gene PTEN has been linked to tumor growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM). Now, Ludwig researchers have shown that one ...
May 12, 2017
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