Medical research
At last, a reason why stress causes DNA damage
For years, researchers have published papers that associate chronic stress with chromosomal damage.
Aug 21, 2011
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News tagged with tumor suppressor p53
Oncology & Cancer
Drug for pancreatic cancer heralds a new strategy for fighting cancer
A treatment for highly aggressive and commonly fatal pancreatic cancer is being developed, reports a University of Houston researcher who has designed a new medicine that can inhibit two of the major pathways of the deadly ...
Sep 11, 2018
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Oncology & Cancer
By decoding how HPV causes cancer, researchers find a new potential treatment strategy
A study that teases apart the biological mechanisms by which human papillomaviruses (HPV) cause cancer has found what researchers at Georgetown University Medical Center say is a new strategy that might provide targeted treatment ...
Oct 2, 2017
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Oncology & Cancer
Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Jan 13, 2013
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Diabetes
Common genetic variant in a tumor suppressor gene linked to obesity and type 2 diabetes
P53, a tumor suppressor gene that is mutated and inactivated in the vast majority of cancers, has often been described as the "guardian of the genome" because of its protective effects against cancer. Now, researchers at ...
Mar 3, 2016
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Medical research
Study finds that a protein that helps suppress cancer fades as we age
Researchers at UCLA have found that a protein that serves as a suppressor of cancer diminishes in skin and mouth epithelial cells as the human body ages.
Jul 16, 2015
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Oncology & Cancer
Team finds key to common cancer pathway
Scientists have long known that the protein p53, when mutated, is a critical factor in the onset of many different kinds of cancer. In its unmutated form, however, it is known to protect against cancer.
Mar 18, 2019
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Oncology & Cancer
How a metabolic pathway promotes breast cancer metastasis
A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The ...
Apr 6, 2016
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Oncology & Cancer
Substance in grapes prevents agglomeration of a mutant protein that leads to cancer
Researchers at the Federal University of Rio de Janeiro (UFRJ) and the State University of Rio de Janeiro (UERJ) have made a discovery that could lead to the development of a treatment against more than half of breast cancer ...
Jun 27, 2018
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Oncology & Cancer
New discoveries about tumor-suppressing protein could help to reduce treatment side effects
Researchers at the Stanford University School of Medicine have untangled two distinct ways in which a common, naturally occurring "tumor-suppressor" protein works. The separation of these two functions — which can have ...
May 12, 2011
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