News tagged with tumor suppressor
Protein preps cells to survive stress of cancer growth and chemotherapy
Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.
Cancer
May 23, 2013 |
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Study details genes that control whether tumors adapt or die when faced with p53 activating drugs
When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die – the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even i ...
Cancer
May 22, 2013 |
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New drug enhances radiation treatment for brain cancer in preclinical studies
A novel drug may help increase the effectiveness of radiation therapy for the most deadly form of brain cancer, report scientists at Virginia Commonwealth University Massey Cancer Center. In mouse models of human glioblastoma ...
Cancer
May 14, 2013 |
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Researchers describe how breast cancer cells acquire drug resistance
A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues ...
Cancer
May 07, 2013 |
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Wip1 could be new target for cancer treatment
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new ...
Cancer
May 06, 2013 |
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Inhibiting enzymes in the cell may lead to development and proliferation of cancer cells
Blocking certain enzymes in the cell may prevent cancer cell division and growth, according to new findings from researchers at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The ...
Cancer
Apr 25, 2013 |
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Deficiency in p53 anti-tumor protein delays DNA repair after radiation
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression ...
Cancer
Apr 23, 2013 |
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Study discovers that stem cell senescence drives aging
Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor ...
Medical research
Apr 18, 2013 |
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Liver cancers armed with many strategies for evading immune response
(Medical Xpress)—Researchers at Roswell Park Cancer Institute (RPCI) have published findings that help explain how a common and particularly resilient form of liver cancer evades the body's natural antitumor responses. ...
Cancer
Apr 18, 2013 |
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Cancer cell metabolism kills
Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply ...
Cancer
Apr 15, 2013 |
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Study finds new drug target for metastatic breast cancer
Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the ...
Cancer
Apr 11, 2013 |
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Excess estrogen in pregnancy can silence BRCA1 in daughters, increasing breast cancer risk
Excess estrogen levels during pregnancy can disable, in their daughters, a powerful breast cancer tumor suppressor gene, say researchers at Georgetown Lombardi Comprehensive Cancer Center. They found the DNA repair gene BRCA1 ...
Cancer
Apr 09, 2013 |
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KDM1 may represent a new therapeutic target for glioma
Researchers have generated preclinical data demonstrating that the protein KDM1, which functions as a lysine demethylase, is a potential target for glioma treatment, according to Gangadhara R. Sareddy, Ph.D., a postdoctoral ...
Cancer
Apr 08, 2013 |
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Researchers say one specific microrna promotes tumor growth and cancer spread
Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in ...
Cancer
Apr 03, 2013 |
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Researchers probe the enigma of healing element that is also the enemy
The same factor in our immune system that is instrumental in enabling us to fight off severe and dangerous inflammatory ailments is also a player in doing the opposite at a later stage, causing the suppression of our immune ...
Immunology
Apr 03, 2013 |
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Tumor suppressor gene
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
For more information about Tumor suppressor gene, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
