A new study by University of Kentucky Markey Cancer Center researchers shows that DACH1 mutations are prevalent in Kentucky patients with endometrial cancer, suggesting that DACH1 may be a candidate biomarker for future trials ...
Jan 12, 2021
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7
Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online ...
Jan 11, 2021
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66
A team of Vanderbilt investigators has discovered that blocking a certain signaling pathway boosts antitumor immunity and reduces tumor growth and metastasis in models of breast cancer and melanoma.
Dec 18, 2020
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204
Researchers at The University of Texas MD Anderson Cancer Center have developed a novel targeted therapy, called POMHEX, which blocks critical metabolic pathways in cancer cells with specific genetic defects. Preclinical ...
Nov 23, 2020
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24
A new study, led by researchers from the University of California, Irvine, has deepened the understanding of epigenetic mechanisms in tumorigenesis and revealed a previously undetected repertoire of cancer driver genes. The ...
Nov 12, 2020
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90
The compound thymoquinone (TQ) selectively kills prostate cancer cells at advanced stages, according to a new study published in Oncogene. Led by researchers at Kanazawa University, the study reports that prostate cancer ...
Oct 7, 2020
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3
The kidneys often become bulky and dysfunctional in diabetes, and now scientists have found that one path to this damage dramatically reduces the kidney's ability to clean up after itself.
Sep 22, 2020
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114
More than 200 genes with novel and known roles in glioblastoma—the most aggressive type of brain cancer—offer promising new drug targets. Researchers from the Wellcome Sanger Institute, Addenbrooke's Hospital and their ...
Jul 29, 2020
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176
An enzyme that blocks the metabolic processes that contribute to the rapid growth and spread of liver cancer has been discovered, according to a study by researchers at Sanford Burnham Prebys and Weill Cornell Medicine. The ...
Jun 26, 2020
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94
The development of pancreatic cancer is driven by co-existing mutations in an oncogene involved in controlling cell growth, called KRAS, and in a tumor suppressor gene, called p53. But how these mutations cooperate to promote ...
Jun 18, 2020
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94
