News tagged with tumorigenesis

Cancer may require simpler genetic mutations than previously thought

Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists haven't known how a deletion in one gene from one parent, called a "hemizygous" deletion, can contribute ...

Cancer May 25, 2012 | 5 / 5 (1) | 0 |

New mechanism for cancer progression discovered

The protein Ras plays an important role in cellular growth control. Researchers have focused on the protein because mutations in its gene are found in more than 30 percent of all cancers, making it the most prevalent human ...

Cancer Nov 27, 2012 | 5 / 5 (1) | 0 |

BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancer

BGI, the world's largest genomics organization, announced that a study on frequent mutation of genes encoding ubiquitin-mediated proteolysis pathway (UMPP) components in clear cell renal cell carcinoma (ccRCC) is published ...

Cancer Dec 04, 2011 | not rated yet | 0 |

Could a tumor suppressor also fight obesity?

The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest ...

Medical research Aug 25, 2011 | not rated yet | 0 |

Exploring lincRNA's role in breast cancer

Once considered part of the "junk" of our genome, much of the DNA between protein-coding genes is now known to be transcribed. New findings by scientists at Fox Chase Cancer Center have identified several dozen transcripts ...

Cancer Apr 08, 2013 | not rated yet | 0

By determining structural effects of tumor-causing mutations, scientists obtain valuable information for drug discovery

(Medical Xpress)—For many patients with non-small-cell lung carcinoma (NSCLC), tumorigenesis is fueled by mutations that hyperactivate the epidermal growth factor receptor (EGFR) signaling protein. These ...

Cancer Feb 15, 2013 | 5 / 5 (1) | 0

The skin aging regulator

Despite progress in regenerative medicine, with age, the skin loses its properties in an irreversible manner. The ATIP-Avenir team "Epidermal homeostasis and tumorigenesis" directed by Chloé Féral, an Inserm ...

Medical research Jan 22, 2013 | 5 / 5 (2) | 0

Bacterial imbalance contributes to intestinal inflammation and carcinogenesis

Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, including inflammatory bowel disease and colorectal cancer; however, it is unclear if dysbiosis ...

Inflammatory disorders Jan 02, 2013 | 5 / 5 (1) | 0