The most common first diagnosis of Alport syndrome in Japan is during the universal age-3 urine screening. In 60% of these children, the disease had already progressed far enough to qualify for treatment. Therefore, universal ...
Oct 7, 2025
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Alport syndrome is a genetic disorder associated with kidney dysfunction, sensorineural hearing loss, and ocular abnormalities. In the kidneys, hematuria occurs in the early stages of the disease, followed gradually by proteinuria ...
Oct 28, 2024
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Chronic kidney disease (CKD) is extremely prevalent among adults, affecting over 800 million individuals worldwide. Many of these patients eventually require therapy to supplement or replace kidney functions, such as dialysis ...
Apr 3, 2024
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Researchers have generated induced pluripotent stem cell (iPSC)-derived kidney organoids to model Alport syndrome caused by a mutation in the COL4A5 gene and have demonstrated the utility of a chemical chaperone to rescue ...
Oct 18, 2023
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