Genetics

CRISPR enhances gene therapy to fight inherited diseases

Gene therapy has shown promise in treating inherited genetic diseases, but a major issue that has frustrated scientists remains: Replacing a "bad" gene with a healthy one often is a short-lived fix. Typically, the healthy ...

Diseases, Conditions, Syndromes

What is the virus that has killed 7 children in New Jersey?

(HealthDay)—New Jersey health officials on Wednesday confirmed the deaths of seven children following infection with an adenovirus—a member of the same viral family that causes the common cold.

Diseases, Conditions, Syndromes

WHO: 1 child has died in mystery liver disease outbreak

The World Health Organization says at least one death has been reported in connection with a mysterious liver disease outbreak affecting children in Europe and the United States.

Diseases, Conditions, Syndromes

Why the mystery hepatitis in children may have been here all along

The children typically show up at hospitals scattered across the country, one or two at a time, with symptoms like unexplained vomiting, diarrhea and jaundice. These are the classic signs of hepatitis—inflammation of the ...

Cardiology

Study could help improve gene therapy for heart disease, cancer

A Loyola University Chicago Stritch School of Medicine study could lead to improved gene therapies for conditions such as heart disease and cancer as well as more effective vaccines for tuberculosis, malaria and other diseases.

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Adenoviruses are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) icosahedral viruses composed of a nucleocapsid and a double-stranded linear DNA genome. There are 57 described serotypes in humans, which are responsible for 5–10% of upper respiratory infections in children, and many infections in adults as well.

Viruses of the family Adenoviridae infect various species of vertebrates, including humans. Adenoviruses were first isolated in 1953 from human adenoids. They are classified as group I under the Baltimore classification scheme, meaning their genomes consist of double stranded DNA.

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