Epilepsy is among the most common neurological conditions, marked by unpredictable seizures, accidents and injuries, reduced quality of life, stigma and—in the worst case—premature death.
Jul 1, 2025
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Researchers at Children's Hospital of Philadelphia (CHOP) have found that in rare instances, variants responsible for SYNGAP1-related disorders—a group of disorders characterized by developmental delay and often associated ...
Jun 19, 2025
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Up to 1 in 3 adults and young people with epilepsy also have mental health conditions such as depression and anxiety. A new set of recommendations aims to help neurologists offer a more integrated approach to care.
Jun 18, 2025
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Epilepsy (from the Ancient Greek ἐπιληψία (epilēpsía) — "seizure") is a common and diverse set of chronic neurological disorders characterized by seizures. Some definitions of epilepsy require that seizures be recurrent and unprovoked, but others require only a single seizure combined with brain alterations which increase the chance of future seizures.
Epileptic seizures result from abnormal, excessive or hypersynchronous neuronal activity in the brain. About 50 million people worldwide have epilepsy, and nearly 90% of epilepsy occurs in developing countries. Epilepsy becomes more common as people age. Onset of new cases occur most frequently in infants and the elderly. As a consequence of brain surgery, epileptic seizures may occur in recovering patients.
Epilepsy is usually controlled, but not cured, with medication. However, over 30% of people with epilepsy do not have seizure control even with the best available medications. Surgery may be considered in difficult cases. Not all epilepsy syndromes are lifelong – some forms are confined to particular stages of childhood. Epilepsy should not be understood as a single disorder, but rather as syndromic with vastly divergent symptoms, all involving episodic abnormal electrical activity in the brain and numerous seizures.
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