Medical research
Could an antibody drug help you shed pounds?
An experimental antibody drug that targets one of the body's key metabolism regulators may help obese people lose weight—at least briefly.
Nov 3, 2020
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38
Fatty Liver Disease
Inflammatory disorders
Researchers discover a mechanism allowing immune cells to regulate obesity
Macrophages are immune system cells. They are essential in the early response to infections, and they also have a key role in the proper functioning of our tissues and the regulation of obesity. Now, researchers at the Centro ...
Sep 18, 2020
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81
Medical research
Researchers find molecular link between liver disease, insulin resistance
Yale researchers have zeroed in on a molecular link between nonalcoholic fatty liver disease and liver insulin resistance in type 2 diabetes. The findings, reported Sept. 2 in the journal Cell Metabolism, will help pave the ...
Sep 2, 2020
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98
Diseases, Conditions, Syndromes
Excessive fructose consumption may cause a leaky gut, leading to fatty liver disease
Excessive consumption of fructose—a sweetener ubiquitous in the American diet—can result in non-alcoholic fatty liver disease (NAFLD), which is comparably abundant in the United States. But contrary to previous understanding, ...
Aug 24, 2020
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894
Diseases, Conditions, Syndromes
The gut shields the liver from fructose-induced damage
After one consumes food or a beverage containing fructose, the gastrointestinal system, or gut, helps to shield the liver from damage by breaking down the sugar before it reaches the liver, according to a new multi-center ...
Jun 29, 2020
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252
Diseases, Conditions, Syndromes
New imaging method could help detect and monitor liver disease
It's currently difficult to screen for certain liver diseases and to monitor these conditions once they're discovered. A team led by investigators at Massachusetts General Hospital (MGH) and the Massachusetts Institute of ...
Jun 23, 2020
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160
Genetics
Premature epigenomic aging acts like a 'sleeper cell' that is awakened by Western-style diet
The epigenome is sometimes referred to as the "software" or "operating system" of the genome. It comprises small chemical modifications to DNA and the proteins that make up our chromosomes, and controls the activity of all ...
Jun 16, 2020
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506
Medical research
Drug researcher develops 'fat burning' molecule that has implications for treatment of obesity
Obesity affects more than 40 percent of adults in the United States and 13 percent of the global population. With obesity comes a variety of other interconnected diseases including cardiovascular disease, diabetes, and fatty ...
Jun 8, 2020
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433
Immunology
How a fat cell's immune response makes obesity worse
When obesity occurs, a person's own fat cells can set off a complex inflammatory chain reaction that can further disrupt metabolism and weaken immune response—potentially placing people at higher risk of poor outcomes from ...
Jun 3, 2020
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392
Medical research
An imbalance of electrons in the liver may be a common risk factor for disease
Researchers at Massachusetts General Hospital have uncovered an unexpected connection between an imbalance of electrons in liver cells and many metabolic problems that increase the risk for conditions such as cardiovascular ...
May 28, 2020
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