Medical research

Muscle health depends on sugar superstructure

For many inherited diseases, such as cystic fibrosis or Huntington disease, the disease-causing genetic mutation damages or removes a protein that has an essential role in the body. This protein defect is the root cause of ...

Genetics

Bacterial genes tell the tale of an outbreak's evolution

Researchers at Harvard Medical School and Children's Hospital Boston have retraced the evolution of an unusual bacterial infection as it spread among cystic fibrosis patients by sequencing scores of samples collected during ...

Medical research

New study furthers understanding of lung regeneration

Researchers at Boston Medical Center (BMC) and Boston University (BU) have published a new study detailing the development of a method for generating human alveolar epithelial type I cells (AT1s) from pluripotent stem cells ...

Diseases, Conditions, Syndromes

New study probes macrophages' role in developing pulmonary fibrosis

Scientists have long known that white blood cells called macrophages accumulate in the lungs of people suffering from pulmonary fibrosis. What role macrophages play in developing the often fatal lung disease is less clear.

Medications

How a new drug prototype regenerates lung tissue

Pulmonary diseases are a leading cause of morbidity and mortality worldwide. For many progressive lung diseases like idiopathic pulmonary fibrosis (IPF), a key issue is a low supply of new stem cells to repair and reverse ...

Diseases, Conditions, Syndromes

Unlocking the secrets of lung fibrosis with a new mouse model

A RIKEN-developed mouse model of an enigmatic lung disease promises to unlock new biological insights and catalyze the development of treatments for millions affected globally. The research is published in Nature Communications.

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Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This is as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue. Scarring is confluent fibrosis that obliterates the architecture of the underlying organ or tissue.

The term is also sometimes used to describe a normal healing process, but this usage is less common.

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