New work from Carnegie's Ethan Greenblatt and Allan Spradling reveals that the genetic factors underlying fragile X syndrome, and potentially other autism-related disorders, stem from defects in the cell's ability to create ...
Aug 16, 2018
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1089
In a new study in mice, researchers have identified a key protein involved in the irregular brain cell activity seen in autism spectrum disorders and epilepsy. The protein, p53, is well-known in cancer biology as a tumor ...
Jul 17, 2018
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112
Research in mice shows that a pharmacological strategy can alleviate multiple behavioral and cellular deficiencies in a mouse model of fragile X syndrome (FXS), the most common inherited form of intellectual disability and ...
Jul 13, 2018
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36
An FDA-approved drug can reverse an ionic imbalance in neurons that leads to hyper-excitability in mice modeling an autism-related genetic disorder, according to a Northwestern Medicine study published in Molecular Psychiatry.
May 8, 2018
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For the first time, UNC School of Medicine researchers have used MRIs to show that babies with the neurodevelopmental condition fragile X syndrome had less-developed white matter compared to infants that did not develop the ...
Apr 4, 2018
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149
Fresh insights into changes in the brain linked to depression could pave the way for new therapies.
Feb 26, 2018
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191
Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting one out of every 3,600 boys born. The syndrome can also cause autistic traits, such as social and communication deficits, as well ...
Feb 16, 2018
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399
Developmental changes in the brainstem driven by fragile X syndrome (FXS)—a condition that often co-occurs with autism spectrum disorder in humans—may underlie the hypersensitivity to sound observed in both humans and ...
Dec 26, 2017
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5
Researchers at Indiana University have found a previously undetected link between the gene that causes fragile X syndrome and increased tissue growth. The link could reveal a key biological mechanism behind the serious physical ...
Dec 5, 2017
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32
Northwestern Medicine scientists have discovered a delay in the maturation of fast-spiking neurons in the neonatal cortex of a mouse model of Fragile X syndrome, a human neurodevelopmental disorder.
Dec 5, 2017
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