Oncology & Cancer

Researchers test novel gene therapy for glioblastoma

A novel gene therapy clinical trial at University Hospitals Seidman Cancer Center and the Case Comprehensive Cancer Center is showing promising results, garnering funding with a prestigious U01 Grant from the National Cancer ...

Oncology & Cancer

Scientists track brain tumor turncoats with advanced imaging

Glioblastomas, the deadliest type of brain tumor in adults, attract "turncoats." These are macrophages, a type of immune cell, which promote tumor progression and mask tumors from the immune system's scrutiny. To better understand ...

Oncology & Cancer

A clear vision for cancer diagnosis

While reading an article about Sen. John McCain's glioblastoma diagnosis, Kavya Kopparapu was shocked to learn that the prognosis for this aggressive brain cancer has not improved over the past 30 years. With standard treatment, ...

Genetics

Study sheds light on the darker parts of our genetic heritage

More than half of our genome consists of transposons,DNA sequences that are reminiscent of ancient, extinct viruses.Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to ...

Oncology & Cancer

New vaccine strategy boosts T-cell therapy

A promising new way to treat some types of cancer is to program the patient's own T cells to destroy the cancerous cells. This approach, termed CAR-T cell therapy, is now used to combat some types of leukemia, but so far ...

Medications

Using a common anticonvulsant to counteract inflammation

Serious conditions, including sepsis, stem from inflammation in the body, and there is a lack of effective medication for sepsis. A chromosomal protein called high-mobility group box 1 (HMGB1), secreted by immune and dying ...

Oncology & Cancer

Scientists discover molecular key to how cancer spreads

Yale researchers have discovered how metastasis, the spread of cancer cells throughout the body, is triggered on the molecular level, and have developed a tool with the potential to detect those triggers in patients with ...

Oncology & Cancer

Novel agent reactivates an immune call by LIF blockade

Results from a study spearhead by researchers at the Vall dĀ“Hebron Institute of Oncology (VHIO), show that the blockade of the multi-functional cytokine LIF induces tumor-infiltrating T cells to target and eliminate cancer. ...

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