Glioblastoma (GBM) is the most aggressive brain tumor in adults. Currently, it can be treated with neurosurgery, radiotherapy and chemotherapy. Still, the median life expectancy of patients affected with this pathology is ...
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MALT1 blockers have long been in clinical use for the treatment of blood cancers. A study suggests that these drugs could potentially also be developed as a treatment option for glioblastoma, the most common and lethal type ...
Nov 27, 2019
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One of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine. Scientists have long noticed that when cancer-causing genes do ...
Nov 21, 2019
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Researchers from the University of São Paulo (USP) in Brazil have developed a strategy for treating the most aggressive type of brain cancer in adults that combines a photoactive molecule and a chemotherapeutic agent—both ...
Nov 27, 2019
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Glioblastoma multiforme, or GBM, is the most frequently occurring and gravest primary tumor of the central nervous system in adults. Poor survival rates among patients with GBM are associated with the development of resistance ...
Nov 14, 2019
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Activation of CD95, a receptor found on all cancer cells, triggers programmed cell death—or does the opposite, namely stimulates cancer cell growth. Scientists from the German Cancer Research Center (DKFZ) have now shown ...
Nov 19, 2019
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Glioblastoma is the most frequent and aggressive brain cancer due to its ability to escape the immune system. However, the way in which this tumor manages to induce this immune tolerance was not known in detail. A research ...
Sep 24, 2019
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Researchers at Karolinska Institutet in Sweden have identified 10 tumour-specific potential drug targets for the brain tumour glioblastoma. The results are presented in the scientific journal Cell Reports.
Nov 05, 2019
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In the story of Goldilocks, a little girl tastes three different bowls of porridge to find which is not too hot, not too cold, but just the right temperature. In a study published in Advanced Therapeutics, University of Minnesota ...
Oct 04, 2019
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A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.
Oct 18, 2019
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A research team from the University of Georgia's Regenerative Bioscience Center has found that a compound molecule used for drug delivery of insulin could be used to treat glioblastoma, an aggressive, usually fatal form of ...
Sep 10, 2019
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A blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream—called a liquid biopsy—correlates with how patients will progress after they are diagnosed with glioblastoma (GBM), the deadliest and most ...
Oct 31, 2019
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One of the deadliest brain tumours forms a genetic force field around itself to protect it from attack by the immune system, scientists have discovered.
Sep 11, 2019
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In a current paper published in the journal Nature, Heidelberg-based researchers and physicians describe how neurons in the brain establish contact with aggressive glioblastomas and thus promote tumor growth / New tumor activation ...
Sep 20, 2019
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Investigators at the University of Cincinnati are studying whether or not a modified Atkins-type ketogenic diet could help make treatments for a common, but dangerous, type of brain cancer called glioblastoma more effective.
Sep 30, 2019
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Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans, involving glial cells and accounting for 52% of all functional tissue brain tumor cases and 20% of all intracranial tumors. Despite being the most prevalent form of primary brain tumor, GBMs occur in only 2–3 cases per 100,000 people in Europe and North America. According to the WHO classification of the tumors of the central nervous system, the standard name for this brain tumor is "glioblastoma"; it presents two variants: giant cell glioblastoma and gliosarcoma. Glioblastomas are also an important brain tumor in canines, and research continues to use this as a model for developing treatments in humans.
Treatment can involve chemotherapy, radiation, radiosurgery, corticosteroids, antiangiogenic therapy, surgery and experimental approaches such as gene transfer.
With the exception of the brainstem gliomas, glioblastoma has the worst prognosis of any central nervous system (CNS) malignancy, despite multimodality treatment consisting of open craniotomy with surgical resection of as much of the tumor as possible, followed by concurrent or sequential chemoradiotherapy, antiangiogenic therapy with bevacizumab, gamma knife radiosurgery, and symptomatic management with corticosteroids. Prognosis is poor, with a median survival time of approximately 14 months.
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