The emergence of COVID-19 had doctors racing to define and treat the new disease, but they soon discovered it was not the only novel illness caused by SARS-CoV-2. A subset of children infected by the virus also experienced ...
May 16, 2022
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Researchers have found genes that make children susceptible to the disease, and those associated with the heart damage it can cause in severe cases.
Apr 14, 2021
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Researchers at University of California San Diego School of Medicine, Scripps Institution of Oceanography, and international collaborators have evidence that Kawasaki Disease (KD) does not have a single cause. By studying ...
Nov 12, 2018
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An international team of scientists, including researchers from the University of California, San Diego, report that the likely causative agent of Kawasaki disease (KD) in Japan is a windborne agent originating from a source ...
May 19, 2014
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Sanford-Burnham Medical Research Institute scientists have discovered a new molecule that forms when certain white blood cells—macrophages—are stimulated in response to pathogens. The molecule, termed "THRIL," helps regulate ...
Dec 26, 2013
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Deborah Copaken Kogan’s Mother’s Day wasn’t exactly what she was hoping for when she woke up to discover her 4-year-old son Leo was sick with a rash. She posted a status message on the social networking site, ...
A study led by ISGlobal shows that the incidence of Kawasaki disease in Japan increases when fine metal-laden aerosols are detected in the atmosphere. These aerosols come from the area known as the "breadbasket of China," ...
Jun 21, 2023
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A new tool under development by University at Buffalo researchers could one day help clinicians better predict resistance to immunoglobulin therapy among children with Kawasaki disease in the United States.
Dec 2, 2022
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For children with rare heart conditions such as Kawasaki disease, heart failure or congenital heart defects that increase the risk of blood clots, a daily anti-clotting pill may safely allow them to avoid the frequent injections, ...
Oct 31, 2022
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One of the rare complications of COVID in children is an inflammatory illness called paediatric inflammatory multisystem syndrome (PIMS-TS) that occurs in the weeks following the time of infection with SARS-CoV-2 (the virus ...
Jun 7, 2022
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Kawasaki disease (KD), also known as Kawasaki syndrome, lymph node syndrome and mucocutaneous lymph node syndrome, is an autoimmune disease in which the medium-sized blood vessels throughout the body become inflamed. It is largely seen in children under five years of age. It affects many organ systems, mainly those including the blood vessels, skin, mucous membranes and lymph nodes; however, its rare but most serious effect is on the heart where it can cause fatal coronary artery aneurysms in untreated children. Without treatment, mortality may approach 1%, usually within six weeks of onset. With treatment, the mortality rate is less than 0.01% in the U.S. There is often a pre-existing viral infection that may play a role in its pathogenesis. The conjunctivae and oral mucosa, along with the epidermis (skin), become erythematous (red and inflamed). Edema is often seen in the hands and feet and one or both of the cervical lymph nodes are often enlarged. Also, a remittent fever, often 40°C (104°F) or higher, is characteristic of the acute phase of the disease. In untreated children, the febrile period lasts on average approximately 10 days, but may range from five to 25 days. The disorder was first described in 1967 by Tomisaku Kawasaki in Japan.
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