Motor Neurone Disease

Homing system delivers drugs to specific neurons

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Fighting canine ALS

A gene-silencing therapy under development for people with amyotrophic lateral sclerosis (ALS) is being tested at Tufts in dogs with degenerative myelopathy, a fatal paralytic disease that is similar to ALS.

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The motor neurone diseases (or motor neuron diseases) (MND) are a group of neurological disorders that selectively affect motor neurones, the cells that control voluntary muscle activity including speaking, walking, breathing, swallowing and general movement of the body. They are generally progressive in nature, and can cause progressive disability and death. The drug riluzole can slow progression slightly; apart from this the medical care is supportive. The condition was first described in full by the French neurologist Jean-Martin Charcot in 1869.

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