Muscular Dystrophy

Doctor discusses pediatric heart pump trial

During the wait for a heart transplant, patients with advanced heart failure can be supported with a ventricular assist device, an artificial pump that helps the heart move blood through the body. But the VAD now used for ...

Apr 19, 2017
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Stem cell consortium tackles complex genetic diseases

Much of stem cell research over the past decade has focused on Mendelian disorders—those caused by a single gene, such as cystic fibrosis, muscular dystrophy, and Huntington's disease. But as genome-wide association studies ...

Apr 06, 2017
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Screening the dark genome for disease

Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation. The technique could revolutionize modern medicine's understanding ...

Apr 03, 2017
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Dietary supplement could improve heart health

Dietary intervention could benefit heart health in those with muscular dystrophy. That's according to new research published in Experimental Physiology. If these findings are confirmed in humans, it could mean that off the ...

Feb 14, 2017
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Muscular dystrophy (MD) is a group of muscle diseases that weaken the musculoskeletal system and hamper locomotion. Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.

In the 1860s, descriptions of boys who grew progressively weaker, lost the ability to walk, and died at an early age became more prominent in medical journals. In the following decade, French neurologist Guillaume Duchenne gave a comprehensive account of thirteen boys with the most common and severe form of the disease, which now carries his name—Duchenne muscular dystrophy.

It soon became evident that the disease had more than one form. The other major forms are Becker, limb-girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, and Emery-Dreifuss muscular dystrophy. These diseases predominately affect males, although females may be carriers of the disease gene. Most types of MD are multi-system disorders with manifestations in body systems including the heart, gastrointestinal system, nervous system, endocrine glands, eyes and brain.

Apart from the nine major types of muscular dystrophy listed above, several MD-like conditions have also been identified. Normal intellectual, behavioral, bowel and sexual function is noticed in individuals with other forms of MD and MD-like conditions. MD-affected individuals with susceptible intellectual impairment are diagnosed through molecular characteristics but not through problems associated with disability. However, a third of patients who are severely affected with DMD may have cognitive impairment, behavioral, vision and speech problems.

This text uses material from Wikipedia licensed under CC BY-SA

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