Oncology & Cancer
Life-extending immunotherapy approved on NHS for children with neuroblastoma
Children in England with high-risk neuroblastoma will now be offered a cancer drug that could extend their life.
Jul 16, 2018
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9
Neuroblastoma
Medical research
New model for predicting neuroblastoma outcomes incorporates early developmental signals
Neuroblastoma, a rare childhood cancer of the sympathetic nervous system, is particularly deadly because it is difficult to detect and thus generally advanced before treatment begins. Scientists know that neuroblastoma develops ...
Jul 6, 2018
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28
Oncology & Cancer
Researchers create novel combination as potential therapy for high-risk neuroblastoma
Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for ...
Jun 18, 2018
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31
Oncology & Cancer
Children with neuroblastoma have an elevated risk of long-term psychological difficulties
A new study reveals that pediatric neuroblastoma patients are at elevated risk for long-term psychological impairment. In addition, those who experience such impairment as they get older tend to require special education ...
Jun 11, 2018
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179
Oncology & Cancer
Anti-inflammatory strategy stops aggressive childhood cancer
Researchers at Karolinska Institutet and Karolinska University Hospital have discovered that an anti-inflammatory drug candidate inhibiting the prostaglandin E2 producing enzyme mPGES-1 in the tumour stroma reduces tumour ...
May 29, 2018
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4
Oncology & Cancer
Removing the enablers: Reducing number of tumor-supporting cells to fight neuroblastoma
Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages—a type of immune cell—can negatively ...
Apr 24, 2018
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6
Oncology & Cancer
A new target for neuroblastoma
Neuroblastoma, a cancer that starts in nerve tissue outside of the brain, is the third most common cancer in children and accounts for about 15 percent of pediatric cancer-related deaths.
Feb 15, 2018
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1
Medical research
Oestrogen causes neuroblastoma cells to mature into neurons
The female sex hormone oestrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that ...
Jan 29, 2018
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11
Oncology & Cancer
'Hijacker' drives cancer in some patients with high-risk neuroblastoma
Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome "hijacks" DNA that regulates other genes. The resulting insights ...
Jan 23, 2018
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34
Oncology & Cancer
Researchers identify an indirect way of countering a key genetic lesion in neuroblastoma
Pediatric cancers tend to have relatively "quiet" genomes compared to tumors in adults. They harbor fewer discrete genetic mutations, especially in genes for readily "druggable" targets (such as protein kinases). Instead, ...
Dec 5, 2017
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