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Inflammatory disorders news

Diseases, Conditions, Syndromes

Treatment for chronic rhinitis yields significant clinical improvements

Neurent Medical, a company developing non-surgical interventions to treat chronic inflammatory sinonasal diseases, has released positive six-month results from the PARAGON clinical study in Ear, Nose & Throat Journal.

Inflammatory disorders

A faulty iron hormone in the skin may be the root cause of psoriasis

Scientists may have uncovered the root cause of psoriasis, a chronic and sometimes debilitating skin disease that affects 2–3% of the global population. The condition is characterized by red, scaly patches that impact the ...

Immunology

Nanobodies help decode the central mechanism of inflammation

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine ...

Medications

FDA approves Bimzelx for three new indications

The U.S. Food and Drug Administration has approved Bimzelx (bimekizumab-bkzx) for the treatment of adults with active psoriatic arthritis (PsA), adults with active nonradiographic axial spondyloarthritis (nr-axSpA) with objective ...

Diseases, Conditions, Syndromes

Houston pollen count has spiked dramatically over the last decade

New data from the Houston area reveals spiking levels of ragweed, elm and cedar elm pollen as well as mold spore counts as we enter the fall season. An allergy expert at Baylor College of Medicine breaks down this information ...

Inflammatory disorders

FDA approves Tremfya for ulcerative colitis

The U.S. Food and Drug Administration has approved Johnson & Johnson's Tremfya (guselkumab) for the treatment of adults with moderately to severely active ulcerative colitis.

Inflammatory disorders

Diagnostic tool identifies puzzling inflammatory diseases in kids

RNA performs a number of biological duties, from delivering genetic information to manufacturing proteins. But RNA is also expelled from cells via cell death or active release, and can then find its way into blood plasma.

Dentistry

Altered blood markers detected in individuals with periodontitis

Individuals with periodontitis have altered concentrations of various proteins in their blood, according to a new study from Umeå University, Sweden. These findings pave the way for research into biomarkers for periodontitis ...

Inflammatory disorders

How the health of your gut microbiome can affect your skin

The skin is the largest organ of the human body. Not only does it act as the first line of defense against external stressors such as environmental toxins, pathogens and pollutants, our skin can also reveal much about our ...

Inflammatory disorders

A more targeted therapy to treat inflammatory bowel disease

Biomedical scientists at the University of California, Riverside, propose a way for drugs to be more effective against inflammatory bowel disease, or IBD, in which the intestine undergoes inflammation.

Diseases, Conditions, Syndromes

COVID-19 severity does not differ for patients with skin conditions

For patients with psoriasis, vitiligo, atopic dermatitis (AD), and chronic urticaria (CU), COVID-19 severity does not differ, but treatment of COVID-19 may affect the course of skin disease, according to a letter to the editor ...

Inflammatory disorders

Melatonin exacerbates asthma

Asthma sufferers generally find their condition gets worse at night. Now, a research group may understand why. Melatonin, a sleep hormone that is sometimes prescribed to treat insomnia, exasperates the constriction of the ...

Medications

Topical tapinarof reduces severity of plaque psoriasis

(HealthDay)—For adults with plaque psoriasis, tapinarof cream is better than vehicle control for reducing disease severity, according to a study published in the Dec. 9 issue of the New England Journal of Medicine.

Medical research

Several protein biomarkers protect against disease development

Inflammatory processes are associated with a large range of human diseases, including rheumatic diseases and allergies. Protein biomarkers are measurable molecules that can have a prognostic value in patients, be used to ...

Medical research

Unlocking the cause of UTI-induced delirium

Cedars-Sinai researchers have found that blocking the action of a protein called interleukin 6 (IL-6), part of the immune system, could resolve the delirium that often accompanies urinary tract infection (UTI) in elderly ...

Diseases, Conditions, Syndromes

SARS-CoV-2 can infect kidneys directly, researchers find

Up to 25 percent of patients' COVID-19 cases involve acute kidney injury—the kidneys' equivalent of a heart attack. Clinicians have suspected that such injuries are a side effect of the immune system's sudden release of ...

Inflammatory disorders

Link between intestinal inflammation and microbiome

Around 500 to 1,000 different types of bacteria, fungi and other microorganisms colonize our intestines. All of them together form the intestinal microbiome. As we now know, these microbes play an important role in maintaining ...

Oncology & Cancer

Colorectal cancer risk up for patients with psoriasis

(HealthDay)—Patients with psoriasis have an increased risk for colorectal cancer (CRC), according to a review published in the December issue of the Journal of the American Academy of Dermatology.

Surgery

Risk for psoriasis reduced after tonsillectomy

(HealthDay)—The risk for psoriasis is reduced among individuals who undergo tonsillectomy, according to a study published in the December issue of the Journal of the American Academy of Dermatology.

Medical research

Respiratory virus reprograms airway epithelial cells

Infection with respiratory syncytial virus during infancy results in metabolic reprogramming of epithelial cells lining the airway, according to a Northwestern Medicine study published in the journal Viruses.

Immunology

Suffering from psoriasis? Blame this trio of proteins

About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds ...

Medications

Blocking hyperinflammatory response by repurposing a cancer drug

As we've seen during the COVID-19 pandemic, serious infections sometimes trigger an excessive inflammatory reaction that does as much harm—or more—than the infection itself. New research at Boston Children's Hospital ...