Genes & Development

Oncology & Cancer

Mechanism explains breast cancer cell plasticity

One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment. Understanding the cellular mechanisms that mediate this cancer cell plasticity ...

Genetics

Kick-starting the genome in early development

After the fertilisation of an egg cell, two become one; two sets of genetic information combine to form a genome. We can think of the egg and sperm as information capsules with stored instructions for starting a new life, ...

Immunology

Inflammation can lead to circadian sleep disorders

Inflammation, which is the root cause of autoimmune disorders including arthritis, Type 1 diabetes, irritable bowel syndrome and Crohn's disease, has unexpected effects on body clock function and can lead to sleep and shiftwork-type ...

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