Genome Biology

Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The

Publisher
BioMed Central
Country
United Kingdom
History
2000–present
Impact factor
6.89 (2011)
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Identical twins can share more than identical genes

An international group of researchers has discovered a new phenomenon that occurs in identical twins: independent of their identical genes, they share an additional level of molecular similarity that influences their biological ...

Jan 09, 2018
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Specific fatty acids may worsen Crohn's disease

Some research has suggested that omega-3 fatty acids, abundant in fish oils, can relieve inflammation in Crohn's disease. But a new study using software developed by Duke scientists hints that we should be paying closer attention ...

Sep 15, 2015
popularity1229 comments 1

Early warning gene signature for Alzheimer's

A 'gene signature' that could be used to predict the onset of diseases, such as Alzheimer's, years in advance has been developed in research published in the open access journal Genome Biology.

Sep 06, 2015
popularity1685 comments 3

The chemistry of memory

Learning requires the chemical adaptation of individual synapses. Researchers have now revealed the impact of an RNA-binding protein that is intimately involved in this process on learning and memory formation and learning ...

Nov 24, 2017
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How do neural cells respond to ischemia?

A group of researchers from the Lomonosov Moscow State University, in collaboration with their Irish colleagues from the University College Cork, has studied the early response of cells to ischemia, which is a restriction ...

May 06, 2015
popularity20 comments 0

Genomic recycling: Ancestral genes take on new roles

One often hears about the multitude of genes we have in common with chimps, birds or other living creatures, but such comparisons are sometimes misleading. The shared percentage usually refers only to genes that encode instructions ...

Sep 18, 2017
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