Genome Biology

Oncology & Cancer

CICERO software enables detection of cancer-causing gene fusions

After years of development, engineering and enhancement, researchers at St. Jude Children's Research Hospital have made publicly available a software system that enables better detection of gene fusions. The system, called ...

Genetics

New method created for identifying genes behind brain tumors

Researchers at Uppsala University have developed a method for identifying functional mutations and their effect on genes relevant to the development of glioblastoma—a malignant brain tumor with a very poor prognosis. The ...

Genetics

New therapeutic targets for infertility and cancer revealed

An analysis of 13,000 tumors highlights two previously overlooked genes as potential new therapeutic targets for cancer treatment. The researchers have also identified potential new therapeutic targets for male infertility. ...

Genetics

Why we differ in our ability to fight off gut infections

Τhe ability of the immune system to fight off bacterial, viral and other invading agents in the gut differs between individuals. However, the biological mechanism by which this happens is not well understood, but at least ...

Genetics

New database enhances genomics research collaboration

Sharing datasets that reveal the function of genomic variants in health and disease has become easier, with the launch of a new, open-source database developed by Australian and North American researchers.

Oncology & Cancer

DNA fracturing rewires gene control in cancer

Understanding the mechanisms that mediate widespread DNA damage in the cancer genome is of great interest to cancer physicians and scientists because it may lead to improved treatments and diagnosis. In this study, a multi-institutional ...

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