Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The
The protein HOXA9 is overexpressed in most acute myeloid leukemia (AML) cases and is associated with poor patient outcomes. However, HOXA9 is a difficult protein to target therapeutically, so researchers at St. Jude Children's ...
Jan 12, 2024
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Professor Asaf Hellman and his research team at the Hebrew University-Hadassah Medical School have unveiled new findings in the realm of methylation-directed regulatory networks. Their study sheds light on the mechanisms ...
Nov 28, 2023
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Much research has been conducted over many decades on diseases that are widespread in large parts of the population, such as cancer and heart disease. As a result, treatment methods have improved enormously thanks to long-term ...
Nov 24, 2023
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Key bladder cancer genes have been uncovered through studying the cancers in cats and dogs, in a significant stride for finding which of many mutations are the most important in the cancer's development.
Aug 28, 2023
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To improve therapies for cancer and other diseases, researchers strive to identify tissue-specific therapeutic targets and diagnostic biomarkers in every patient. Identifying specific targets and biomarkers can be achieved ...
Aug 22, 2023
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All human beings are genetically very similar, sharing approximately 99.9% of the DNA code. The remaining 0.1% explains the natural differences between people, including our predisposition to hereditary diseases.
May 3, 2023
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The gut microbiome comprises a complex population of different bacterial species that are essential to human health. In recent years, scientists across several fields have found that changes in the gut microbiome can be linked ...
Mar 29, 2023
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A new study published in Genome Biology has challenged the traditional view that aging is a result of the accumulation of damage to the body's hardware, such as the molecular damage to cells caused by oxidative stress. Instead, ...
Mar 28, 2023
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Twenty years ago, after the human genome was first sequenced, geneticists began conducting large genome-wide association studies to identify genomic regions linked to human disease. In addition to DNA sequence, another stable ...
Jan 12, 2023
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How much do genes influence our body weight? For the general population this influence is around 20%, according to studies that in recent years have analyzed the complete genome of tens of thousands of people. In other words, ...
Nov 8, 2022
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