Genome Biology

Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The

Publisher
BioMed Central
Country
United Kingdom
History
2000–present
Website
http://genomebiology.com
Impact factor
6.89 (2011)

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Genetics

Biological clock able to measure age of most human tissues

Everyone grows older, but scientists don't really understand why. Now a UCLA study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process. Published ...

Genetics

Identical twins can share more than identical genes

An international group of researchers has discovered a new phenomenon that occurs in identical twins: independent of their identical genes, they share an additional level of molecular similarity that influences their biological ...

Genetics

It's true: Latinos age slower than other ethnicities

A UCLA study is the first to show that Latinos age at a slower rate than other ethnic groups. The findings, published in the current issue of Genome Biology, may one day help scientists understand how to slow the aging process ...

Genetics

Specific fatty acids may worsen Crohn's disease

Some research has suggested that omega-3 fatty acids, abundant in fish oils, can relieve inflammation in Crohn's disease. But a new study using software developed by Duke scientists hints that we should be paying closer attention ...

Genetics

Early warning gene signature for Alzheimer's

A 'gene signature' that could be used to predict the onset of diseases, such as Alzheimer's, years in advance has been developed in research published in the open access journal Genome Biology.

Genetics

A treasure map to understanding the epigenetic causes of disease

More than 15 years after scientists first mapped the human genome, most diseases still cannot be predicted based on one's genes, leading researchers to explore epigenetic causes of disease. But the study of epigenetics cannot ...

Autism spectrum disorders

Placenta may hold clues for early autism diagnosis and intervention

New UC Davis MIND Institute research has identified a novel human gene linked to fetal brain development and autism spectrum disorder (ASD). The discovery also links the gene to the mother's early prenatal vitamin use and ...

Oncology & Cancer

Covert inflammation may trigger many forms of cancer

A previously unidentifiable type of low-grade inflammation may explain why common anti-inflammatory drugs such as aspirin have shown promise against some types of cancer – even when patients don't display typical signs ...

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