Journal of Clinical Investigation

Medical research

Gene fuels age-related obesity and diabetes

Practically everyone gets fatter as they get older, but some people can blame their genes for the extra padding. Researchers have shown that two different mutations in a gene called ankyrin-B cause cells to suck up glucose ...

Diseases, Conditions, Syndromes

Study links patrolling monocytes to lupus-related kidney disease

A study led by St. Jude Children's Research Hospital has found evidence suggesting that patrolling monocytes may drive glomerulonephritis, inflammation of the kidneys, in patients with lupus. The findings overturn the previously ...

Medical research

New strategies against rare, fatal lung syndrome

Hermansky-Pudlak syndrome (HPS) patients suffer symptoms including albinism, visual impairment, and slow blood clotting, but what makes some versions of the genetic condition fatal is that patients with some forms of the ...

Neuroscience

Study: Protein key to charcot-marie-tooth, other nerve diseases

A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease. The findings point to a pathway to possible treatments for this disease ...

Inflammatory disorders

New therapeutic strategy to prevent gastrointestinal disease

Food allergies, celiac disease, inflammatory bowel disease (IBD), diarrhea and other gastrointestinal diseases have something in common: all have been linked to epithelial barrier loss. The gut epithelial barrier—that critical ...

Diabetes

Identifying the 'dimmer switch' of diabetes

Patrick MacDonald has dedicated much of his life to diabetes research. It's a job he knows is far too large and complex for any one person, but with his latest publication, he knows his work is playing a part.

Alzheimer's disease & dementia

Scientists find new link between diabetes and Alzheimer's

Researchers have uncovered a unique connection between diabetes and Alzheimer's disease, providing further evidence that a disease that robs people of their memories may be affected by elevated blood sugar, according to scientists ...

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