Journal of Clinical Investigation

Medical research

Stressed mitochondria help cells survive respiratory infections

Many respiratory infections, such as influenza or COVID-19 add significant stress to cells and organs, which can lead to acute respiratory distress syndrome (ARDS), which itself can eventually cause death in aged or sensitive ...

Oncology & Cancer

Epigenetic 'priming' boosts ovarian cancer immunotherapy

An epigenetic inhibitor can boost immune system activity in patients with ovarian cancer, making them more suitable for treatment with immunotherapy, according to a Northwestern Medicine study published in the Journal of ...

Medical research

Scientists decipher the danger of gummy phlegm in severe COVID-19

Stanford University scientists have implicated a logjam of three long, stringy substances behind deadly thick sputum in COVID-19 patients who need a machine to help them breathe. One of these substances may prove especially ...

Medical research

Regulator of cancer 'stemness' discovered

The protein FOXK2 promotes survival of cancer stem cells in ovarian cancer, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

Genetics

The surprising twist behind a rare neurological disorder

A fruit fly study, by an international group of researchers, has pinpointed how a genetic mutation causes one of the important molecular machines in our cells to malfunction. The findings provide a biological mechanism behind ...

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