CFTR is an important protein that, when mutated, causes the life-threatening genetic disease cystic fibrosis. A study in The Journal of General Physiology (JGP) details how an accidental discovery has provided new understanding ...
Sep 26, 2012
0
0
A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ...
Sep 7, 2022
0
69
A study in The Journal of General Physiology helps explain how nicotine exploits the body's cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.
Dec 30, 2013
0
0
Researchers have discovered that mice with Huntington's disease (HD) suffer defects in muscle maturation that may explain some symptoms of the disorder. The study, "Progressive Cl− channel defects reveal disrupted skeletal ...
Nov 29, 2016
0
34
A new study in the Journal of General Physiology provides fresh insight into voltage-gated channels—transmembrane ion channels that play a critical role in the function of neuronal and muscle tissue.
Dec 12, 2011
0
0
Two studies in The Journal of General Physiology (JGP) help pave the way for a "shortcut" model-free approach to studying activation of "polymodal" ion channels—channels that open in response to multiple stimuli.
Dec 27, 2012
0
0
Researchers used induced pluripotent stem cells (iPSCs) derived from a young patient with Long QT syndrome (LQTS), a congenital heart disorder, to determine a course of treatment that helped manage the patient's life-threatening ...
Jan 11, 2013
0
0
Researchers at the University of Vermont College of Medicine have made a discovery that helps explain how we know when to empty our bladders and may lead to new therapeutic interventions for bladder dysfunction.
Mar 28, 2016
0
0
A study in The Journal of General Physiology presents new methods to evaluate how astrocytes contribute to brain function, paving the way for future exploration of these important brain cells at unprecedented levels of detail.
Apr 29, 2013
0
0
Researchers have performed the first human-based study to identify calcium channels in cerebral arteries and determine the distinct role each channel plays in helping control blood flow to the brain. The study appears in ...
Apr 27, 2015
0
7
