Journal of General Physiology

Medical research

Nicotine exploits COPI to foster addiction

A study in The Journal of General Physiology helps explain how nicotine exploits the body's cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.

Medical research

A model-free way to characterize polymodal ion channel gating

Two studies in The Journal of General Physiology (JGP) help pave the way for a "shortcut" model-free approach to studying activation of "polymodal" ion channels—channels that open in response to multiple stimuli.

Medical research

New methods to explore astrocyte effects on brain function

A study in The Journal of General Physiology presents new methods to evaluate how astrocytes contribute to brain function, paving the way for future exploration of these important brain cells at unprecedented levels of detail.

Medical research

Study offers new insights into the mechanics of muscle fatigue

A study in The Journal of General Physiology examines the consequences of muscle activity with surprising results, indicating that the extracellular accumulation of potassium that occurs in working muscles is considerably ...

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