Journal of Medicinal Chemistry

Medications

Another promising step toward non-hormonal male contraceptives

Despite birth control existing for decades, almost none of the options specifically target sperm cells. Researchers are now developing approaches that target testosterone or otherwise interrupt the sperm's ability to fertilize ...

Oncology & Cancer

Photodynamic therapy offers promise for cancer treatment

While chemotherapy drugs can be lifesaving, they don't work for all patients or for all cancers. But a team of UTM researchers is looking at new ways to use special types of light to target cancer cells resistant to current ...

Medical research

Discovery suppresses progression of kidney fibrosis

Webster Santos is determined to find a way to halt kidney fibrosis, a condition caused by persistent inflammation and assault to the kidney. The disorder leads to kidney disease, itself a pathway to kidney failure, also known ...

Oncology & Cancer

Cancer immunotherapy capable of modulating tumor immunophenotypes

Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment. However, there still exists an unmet medical need due to the low response ...

Medical research

Novel inhibitor discovered for B-cell lymphoma treatment

A potent and selective enhancer of zeste homolog 2 (EZH2) inhibitor IHMT-EZH2-115 was recently discovered by researchers led by Prof. Liu Qingsong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences ...

Neuroscience

Ways to enhance neurolysin activity in the brain

Ischemic stroke, the second leading cause of death worldwide, occurs when a vessel to the brain is blocked, reducing blood flow to the brain and depriving it of critical supplies of oxygen and nutrients. This process leads ...

Medical research

Sunflower peptide as template for potential analgesic

A naturally occurring peptide in sunflower seeds was synthetically optimized and has now been identified as a potential drug for treating abdominal pain or inflammation (in the gastrointestinal tract, abdominal area and/or ...

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