Molecular Cell

Genetics

Killer T vs. memory: DNA isn't destiny for T cells

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical. The researchers ...

Neuroscience

Research reveals how the most common ALS mutation dooms cells

St. Jude Children's Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. The research suggests possible new approaches ...

Medical research

Mouse and human skin cells produce melanin on a 48-hour cycle

Researchers have discovered that mouse skin and skin cells from humans produce pigmentation in response to sunlight on a 48-hour cycle. They observed that exposing skin to ultraviolet light every 2 days yielded darker pigmentation ...

Neuroscience

Finding a cause of neurodevelopmental disorders

Neurodevelopmental disorders arising from rare genetic mutations can cause atypical cognitive function, intellectual disability, and developmental delays, yet it is unclear why and how this happens. Scientists suspected a ...

Medical research

'Cellular memory' of DNA damage in oocyte quality control

Females are born with a finite number of eggs that are steadily depleted throughout their lifetime. This reserve of eggs is selected from a much larger pool of millions of precursor cells, or oocytes, that form during fetal ...

Medical research

Researchers find potential treatment for Rett Syndrome

An experimental cancer drug can extend the life of mice with Rett Syndrome, a devastating genetic disorder that afflicts about one of every 10,000 to 15,000 girls within 6 to 18 months after birth, Yale researchers report ...

Medical research

In cells, some oxidants are needed

Within our bodies, high levels of reactive forms of oxygen can damage proteins and contribute to diabetic complications and many other diseases. But some studies are showing that these reactive oxygen species (ROS) molecules ...

Oncology & Cancer

Scientists discover roles for a cellular motor in cancer

Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell.

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