Toxicology and Applied Pharmacology

Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products. Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged. Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.

Publisher
Elsevier
Impact factor
4.447 (2011)

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Medical research

Low-dose radiation impacts skin sensitivity

In experiments where human skin tissue samples were exposed to low doses of ionizing radiation, scientists at Pacific Northwest National Laboratory found that a skin tissue model showed perturbations that suggest its stability ...

Health

The phthalate DEHP undermines female fertility in mice

Two studies in mice add to the evidence that the phthalate DEHP, a plasticizing agent used in auto upholstery, baby toys, building materials and many other consumer products, can undermine female reproductive health, in part ...

Health

Man trumps dog: Earlier assumption about BPA exposure confirmed

Coating the mouth with BPA-containing food, like soup, does not lead to higher than expected levels of BPA in blood, a new study in Toxicology and Applied Pharmacology shows. The study authors conclude that oral exposure ...

Overweight & Obesity

Fetal exposure to nicotine increases long-term risk of obesity

Many women are encouraged to quit smoking when they become pregnant using nicotine replacement therapy (NRT) whether as gum, transdermal patches, nasal spray or lozenges. But new research from Western University in London, ...

Medical research

Discovery may lead to new treatments for jaundice

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.