Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products. Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged. Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.
When scientists exposed pregnant mice to levels of bisphenol A equivalent to those considered safe in humans, three generations of female mouse offspring experienced significant reproductive problems, including declines in ...
Apr 15, 2015
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92
The human-made chemicals that make our kitchen pans stick-free, our athletic wear water-repellent and firefighting chemicals more efficient do their jobs incredibly well, but it's at the expense of lingering in the body and ...
Feb 5, 2020
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389
A Duke University-led study shows how exposure to the particulate matter from cigarette smoke may affect early development in zebrafish embryos and increases the risk of neurological disorders and physical deformities.
Oct 4, 2016
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0
The active ingredient in medicines commonly used to treat yeast infections has the potential to disrupt steroid hormone levels, according to a study from the National Food Institute, Technical University of Denmark. This ...
Jun 16, 2021
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4
Exposure to the chemical glyphosate changed the level of some ovarian proteins in mice but did not impact ovarian steroid production, an indication glyphosate may not adversely affect reproduction, according to a new study.
Jul 28, 2020
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0
Chemical compounds found in many consumer products could be major contributors to the onset of lipid-related diseases, such as obesity, in humans, according to a Baylor University study.
May 19, 2020
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83
A phthalate found in many plastic and personal care products may decrease fertility in female mice, a new study found.
Feb 7, 2019
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18
Grocery shopping can be an illuminating chore for a toxicologist.
May 28, 2018
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240
Two studies in mice add to the evidence that the phthalate DEHP, a plasticizing agent used in auto upholstery, baby toys, building materials and many other consumer products, can undermine female reproductive health, in part ...
Apr 16, 2015
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11
In experiments where human skin tissue samples were exposed to low doses of ionizing radiation, scientists at Pacific Northwest National Laboratory found that a skin tissue model showed perturbations that suggest its stability ...
Apr 6, 2015
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