North American researchers eye ALS vaccine

October 5, 2007

Researchers from U.S. and Canadian universities said they are working on a vaccine for treating the degenerative condition known as Lou Gehrig's disease.

The researchers are developing a vaccine that would target a toxic protein in people with the genetic mutation -- found in a small percentage of cases of the neuro-muscular disease amyotrophic lateral sclerosis, the Montreal Gazette reported Friday.

"The particular protein that has been the subject of much discussion is one that is made in every cell of the body in very high quantities," Harvard University neuro-scientist Robert Brown said at the Montreal Neurological Institute, which is conducting a symposium this week on ALS.

In people with the genetic mutation, the protein becomes toxic, changing in a way that causes it to become unstable, "probably impairing many, many aspects of the motor neurons that will die," he said.

Brown and researchers from Universite Laval in Quebec City are conducting more research on the Canadians' work that showed such a vaccine targeting the toxic protein was effective in lab mice genetically bred with ALS.

Copyright 2007 by United Press International

Explore further: Toxic flame retardants are a burning issue

Related Stories

Toxic flame retardants are a burning issue

January 17, 2018
Flame retardants are an integral part of creating products from plastics to textiles that are fire friendly. However, many of the flame retardants in use are toxic and damaging for the environment. Dr. Giulio Malucelli has ...

Researchers identify new treatment target for melanoma

January 16, 2018
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous ...

Presurgical targeted therapy delays relapse of high-risk stage 3 melanoma

January 17, 2018
A pair of targeted therapies given before and after surgery for melanoma produced at least a six-fold increase in time to progression compared to standard-of-care surgery for patients with stage 3 disease, researchers at ...

New study validates clotting risk factors in chronic kidney disease

January 17, 2018
In late 2017, researchers from Boston University School of Medicine (BUSM) discovered and published (Science Translational Medicine, (9) 417, Nov 2017) a potential treatment target to prevent chronic kidney disease (CKD) ...

Cancer overrides the circadian clock to survive

December 28, 2017
Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina (MUSC) find. A key part of the ...

Research shows biological clocks could improve brain cancer treatment

January 10, 2018
Biological clocks throughout the body play a major role in human health and performance, from sleep and energy use to how food is metabolized and even stroke severity. Now, Texas A&M University researchers found that circadian ...

Recommended for you

In most surgery patients, length of opioid prescription, number of refills spell highest risk for misuse

January 17, 2018
The possible link between physicians' opioid prescription patterns and subsequent abuse has occupied the attention of a nation in the throes of an opioid crisis looking for ways to stem what experts have dubbed an epidemic. ...

Patients receive most opioids at the doctor's office, not the ER

January 16, 2018
Around the country, state legislatures and hospitals have tightened emergency room prescribing guidelines for opioids to curb the addiction epidemic, but a new USC study shows that approach diverts attention from the main ...

FDA bans use of opioid-containing cough meds by kids

January 12, 2018
(HealthDay)—Trying to put a dent in the ongoing opioid addiction crisis, the U.S. Food and Drug Administration on Thursday slapped strict new restrictions on the use of opioid-containing cold and cough products by kids.

Taking ibuprofen for long periods found to alter human testicular physiology

January 9, 2018
A team of researchers from Denmark and France has found that taking regular doses of the pain reliever ibuprofen over a long period of time can lead to a disorder in men called compensated hypogonadism. In their paper published ...

Nearly one-third of Canadians have used opioids: study

January 9, 2018
Nearly one in three Canadians (29 percent) have used "some form of opioids" in the past five years, according to data released Tuesday as widespread fentanyl overdoses continue to kill.

Growing opioid epidemic forcing more children into foster care

January 8, 2018
The opioid epidemic has become so severe it's considered a national public health emergency. Addiction to prescription painkillers, such as oxycodone and morphine, has contributed to a dramatic rise in overdose deaths and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.