Post-stroke clot-busting therapy beneficial for patients on aspirin

March 10, 2008

Patients given a clot-busting drug following stroke appear to have better outcomes if they were already taking anti-platelet medications, despite an apparent increased risk for bleeding in the brain, according to an article posted online today that will appear in the May 2008 print issue of Archives of Neurology.

Dissolving blood clots by administering the drug tissue plasminogen activator (tPA) appears to improve outcomes in some patients with stroke, according to background information in the article. However, the medication is associated with a 10-fold increased risk of symptomatic brain hemorrhage (bleeding). Antiplatelet medications, such as aspirin, might further increase the risk for bleeding because these drugs impair the function of cells critical in forming blood clots.

Maarten Uyttenboogaart, M.D., and colleagues at the University of Groningen, Groningen, the Netherlands, studied 301 patients who received tPA following stroke between 2002 and 2006. Of those, 89 had used antiplatelet drugs prior to receiving tPA.

Symptomatic brain hemorrhages occurred in 12 patients who had received antiplatelet therapy (13.5 percent) and six patients who had not (2.8 percent). Patients who had been taking antiplatelet therapy had a higher risk for symptomatic brain hemorrhages. “Despite this increased risk, prior antiplatelet therapy increased the odds of a favorable outcome,” defined as the ability to independently carry out activities of daily living after three months, the authors write. “Therefore, our study suggests that tPA treatment should not be withheld from patients receiving antiplatelet therapy.”

Source: JAMA and Archives Journals

Explore further: High platelet reactivity tied to ischemic, bleeding outcomes

Related Stories

High platelet reactivity tied to ischemic, bleeding outcomes

August 16, 2017
(HealthDay)—There is a strong relationship between high on-clopidogrel platelet reactivity and two-year ischemic and bleeding outcomes after drug-eluting stent implantation, according to a study published online Aug. 2 ...

Antiplatelet drugs are often inappropriately prescribed in older patients

July 19, 2017
A study has found that antiplatelet drugs, such as aspirin, are often inappropriately prescribed in acutely hospitalized older people.

Study: AHA guidelines to treating patients with coronary artery disease

June 27, 2017
The most recent dual antiplatelet guidelines from the American Heart Association and the American College of Cardiology encourage healthcare providers to take a customized approach to treating patients with coronary artery ...

Risk up for triple Tx versus DAPT in DES implantation with A-fib

May 23, 2017
(HealthDay)—For patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES), atrial fibrillation (AF) is associated with increased risks, with no benefit and higher risk seen for triple therapy ...

COPD exacerbations in those with CVD may increase heart attack/stroke risk

May 21, 2017
After an acute exacerbation of chronic obstructive pulmonary disease, or COPD, people with a history of cardiovascular disease (CVD) or people at risk for CVD appear more likely to suffer a heart attack or stroke, according ...

Embolic protection device useful post carotid artery stenting

June 21, 2017
(HealthDay)—For patients with carotid stenosis, use of an embolic protection device is associated with reduced risk for in-hospital stroke or death, major stroke or death, and stroke after carotid artery stenting, according ...

Recommended for you

Female mouse embryos actively remove male reproductive systems

August 17, 2017
A protein called COUP-TFII determines whether a mouse embryo develops a male reproductive tract, according to researchers at the National Institutes of Health and their colleagues at Baylor College of Medicine, Houston. The ...

New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine

August 17, 2017
A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns ...

Two-step process leads to cell immortalization and cancer

August 17, 2017
A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated process than originally ...

New technique overcomes genetic cause of infertility

August 17, 2017
Scientists have created healthy offspring from genetically infertile male mice, offering a potential new approach to tackling a common genetic cause of human infertility.

Inhibiting a protein found to reduce progression of Alzheimer's and ALS in mice

August 17, 2017
(Medical Xpress)—A team of researchers with Genetech Inc. and universities in Hamburg and San Francisco has found that inhibiting the creation of a protein leads to a reduction in the progression of Alzheimer's disease ...

Are stem cells the link between bacteria and cancer?

August 17, 2017
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.