Worth the effort? Not if you're depressed

August 12, 2009
Individuals suffering from anhedonia, a key symptom of depression, are less likely to pursue rewards if effort is required to obtain the reward. Credit: Michael Treadway, Vanderbilt University

New research indicates that decreased cravings for pleasure may be at the root of a core symptom of major depressive disorder. The research is in contrast to the long-held notion that those suffering from depression lack the ability to enjoy rewards, rather than the desire to seek them.

The research, led by Vanderbilt psychologists Michael Treadway and David Zald, was published Aug. 12 by the online journal .

"This initial study shows that decreased reward processing, which is a core symptom of depression, is specifically related to a reduced willingness to work for a reward," Treadway, a graduate student in psychology, said.

Decreased motivation to seek and experience pleasurable experiences, known as anhedonia, is a primary symptom of . Anhedonia is less responsive to many and often persists after other symptoms of depression subside. However, understanding the different components of anhedonia - the desire to obtain something pleasurable versus experiencing pleasure - has been difficult for researchers to determine in humans.

"In the last decade and a half, animal models have found that the dopamine, long known to be involved in reward processing, is involved in craving or motivation, but not necessarily enjoyment," Treadway said. "To date, research into reward processing in individuals with anhedonia has focused on enjoyment of rewards, rather than assessing the drive to work for them. We think this task is one of the first to do that."

Treadway and his colleagues devised the Effort-Expenditure for Rewards Task, or EEfRT, to explore the role of reduced desire and motivation in individuals reporting symptoms of anhedonia. EEfRT involved having individuals play a simple video game that gave them a chance to choose between two different tasks, one hard, one difficult, to obtain monetary rewards. Participants were eligible but not guaranteed to receive money each time they completed a task successfully.

The "hard" task required pressing a button 100 times within 21 seconds using one's non-dominant little finger and carried a potentially higher reward than the easy task, which required pressing a button 30 times in seven seconds using one's dominant index finger. The subjects were told at the beginning of each trial whether they had a high, medium or low probability of winning a prize if they successfully completed the trial. The participants could choose which trials they completed and were given 20 minutes to perform as many tasks as possible.

The researchers found that subjects who reported symptoms consistent with anhedonia where less willing to make choices requiring greater effort in exchange for greater reward, particularly when the rewards were uncertain.

"Consistent with our hypotheses, we found that individuals with self-reported anhedonia made fewer hard-task choices," the authors wrote. "These findings are consistent with theoretical models linking anhedonia to decreased (dopamine levels)."

"By addressing the motivational dimension of anhedonia, our findings suggest a plausible theoretical connection between dopamine deficiency and reward processing in , which may eventually help us better understand how anhedonia responds to treatment," Treadway said.

Source: Vanderbilt University (news : web)

Related Stories

Recommended for you

When male voles drink alcohol, but their partner doesn't, their relationship suffers

November 17, 2017
A study of the effect of alcohol on long-term relationships finds that when a male prairie vole has access to alcohol, but his female partner doesn't, the relationship suffers - similar to what has been observed in human ...

Risk of distracted driving predicted by age, gender, personality and driving frequency

November 17, 2017
New research identifies age, gender, personality and how often people drive as potential risk factors for becoming distracted while driving. Young men, extroverted or neurotic people, and people who drive more often were ...

Spanking linked to increase in children's behavior problems

November 16, 2017
Children who have been spanked by their parents by age 5 show an increase in behavior problems at age 6 and age 8 relative to children who have never been spanked, according to new findings in Psychological Science, a journal ...

Multiplayer video games: Researchers discover link between skill and intelligence

November 15, 2017
Researchers at the University of York have discovered a link between young people's ability to perform well at two popular video games and high levels of intelligence.

Generous people give in a heartbeat—new study

November 15, 2017
Altruistic people are said to be "kind hearted" - and new research published in the journal Scientific Reports shows that generous people really are more in touch with their own hearts.

Teenage depression linked to father's depression

November 15, 2017
Adolescents whose fathers have depressive symptoms are more likely to experience symptoms of depression themselves, finds a new study led by UCL researchers.


Adjust slider to filter visible comments by rank

Display comments: newest first

5 / 5 (1) Aug 13, 2009
i think i'll go smoke a ciggarette
5 / 5 (1) Aug 13, 2009
An interesting confirmation of my own experience with depression. Evaluation of depression always asks about enjoying activities. Why bother? prevents me from seeking out the activity in the first place.
not rated yet Aug 13, 2009
Yeah, like the other 'gotcha': Not Passive-Aggressive Condition, but old-fashioned 'Compliance Fatigue'...
not rated yet Aug 13, 2009
Quitting is also a decision: a hard one.
5 / 5 (1) Aug 13, 2009
My experience with anhedonia agrees with this article. None of the antidepressants really cured it except for one which worked on serotonin AND dopamine. Just serotonin or dopamine alone didn't do it. And of course I went to therapy to figure out what goals I should be working towards to actually make me happy once I had the motivation to fix things.
not rated yet Aug 13, 2009
But in this test what was the most logical way to get the best reward? - Since you only had 20 minutes, wouldn't it be best to concentrate on the easier tasks where you had a more likely chance of getting a reward, in order to get the most amount of money at the end?
not rated yet Aug 15, 2009
@fuzz54 - what was the name of that drug that worked? i would like to suggest my father's doctor look into it.
not rated yet Oct 12, 2009
The drug I took that had serotonin and dopamine was Effexor XR. There is now a generic version of this drug available. Effexor can have significant withdrawl symptoms though, so it can be hard to get off of and can be awful if you forget a dose and don't have access to it. I'm not having any problems though and am successfully dropping my dosage with no side effects.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.