Acute kidney injury patients more likely to need dialysis within 5 years

September 15, 2009

Patients who sustain injury to their kidneys and require in-hospital dialysis are three times more likely to need long-term dialysis later in life compared to those without a history of this condition, says a new study from St. Michael's Hospital. Patients with acute kidney disease are a high-risk group for whom early medical surveillance and intervention may prevent progression to irreversible end-stage kidney disease.

Approximately two million Canadians have and more than 20,000 of these individuals receive ongoing chronic dialysis, according to the Kidney Foundation of Canada.

The study, published in the September 16 issue of the (JAMA), is the largest study to date to look at the long-term health implications for patients who have experienced acute kidney injury.

"Now that we understand that having acute kidney injury multiplies the risk of future kidney complications, we as physicians can increase the monitoring of these patients and address complications as they occur. If we do this, we may be able to prevent these patients from needing chronic dialysis," said Dr. Ron Wald, the study's lead investigator.

Dr. Wald and his colleagues, including St. Michael's Hospital researchers Drs. Joel Ray and Muhammad Mamdani, studied provincial health records from adult patients across Ontario, using healthcare databases at the Institute for Clinical Evaluative Services (ICES).

The research team identified hospitalized patients in Ontario with an episode of acute kidney injury requiring dialysis between 1996 and 2006 and evaluated their long-term risk of both chronic dialysis and death. These 3,769 individuals survived free of dialysis for at least 30 days after discharge and were matched with 13,598 patients who were equally as ill but without acute kidney injury or dialysis during their hospitalization. The patients were followed for a maximum of 10 years through March 2007.

An editorial that appears in the same issue of JAMA noted "the report by Wald and colleagues…provides valuable insights into the complex complications faced by survivors of an episode of severe acute kidney injury."

Source: St. Michael's Hospital

Related Stories

Recommended for you

New cellular approach found to control progression of chronic kidney disease

December 15, 2017
Researchers have demonstrated for the first time that extracellular vesicles - tiny protein-filled structures - isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage ...

Testing shows differences in efficacy of Zika vaccines after one year

December 15, 2017
(Medical Xpress)—A large team of researchers with members from Harvard Medical School, Walter Reed Army Institute of Research, Bioqual Inc. and MIT has found that the efficacy of the three types of Zika vaccines currently ...

How to regulate fecal microbiota transplants

December 15, 2017
(Medical Xpress)—A small team of researchers at the University of Maryland, some with affiliations to the Veterans Affairs Maryland Health Care System, has written and published a Policy Forum piece in the journal Science ...

Screening could catch a quarter of hip fractures before they happen

December 15, 2017
Community screening for osteoporosis could prevent more than a quarter of hip fractures in older women - according to new research led by the University of East Anglia (UEA).

Urine test developed to test for tuberculosis

December 14, 2017
(Medical Xpress)—An international team of researchers has developed a urine test that can be used to detect tuberculosis (TB) in human patients. In their paper published in Science Translational Medicine, the group describes ...

40 years after first Ebola outbreak, survivors show signs they can stave off new infection

December 14, 2017
Survivors of the first known Ebola outbreak, which occurred in the Democratic Republic of the Congo in 1976, may be key to development of vaccines and therapeutic drugs to treat future outbreaks, according to a new study ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.